Gender and sex considerations in HIV and bone health.
Curr Opin HIV AIDS
; 18(2): 75-80, 2023 03 01.
Article
en En
| MEDLINE
| ID: mdl-36722195
ABSTRACT
PURPOSE OF REVIEW People with HIV (PWHIV) are at increased risk for osteoporosis and fractures, because of the effects of HIV and inflammation and antiretroviral therapy (ART) initiation as well as traditional risk factors. This review from recent literature focuses on sex differences in rates of bone disease, risk of fractures, and effects of ART. RECENT FINDINGS:
Women with HIV in resource-constrained settings experience bone loss because of the additive effect of initiating TDF-containing ART during pregnancy, lactation, and menopause. Children and adolescents experience lower bone accrual during the pubertal growth years. There has been less focus on bone health in recent trials of ART containing tenofovir alafenamide and/or integrase inhibitors. Very few clinical trials or studies compare sex-specific changes in inflammation, immune activation, response to ART and bone turnover or change in BMD resulting in significant knowledge gaps.SUMMARY:
More data is needed to determine changes in prevalence of osteopenia, osteoporosis, and fractures in the era of immediate initiation of ART at high CD4 cell counts and the use of more bone-friendly ART. The long-term effects of ART and low bone mass on fractures in the ageing population of PWHIV is yet to be realized.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Osteoporosis
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Infecciones por VIH
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Fracturas Óseas
Tipo de estudio:
Etiology_studies
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Risk_factors_studies
Límite:
Adolescent
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Child
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Female
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Humans
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Male
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Pregnancy
Idioma:
En
Revista:
Curr Opin HIV AIDS
Asunto de la revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Año:
2023
Tipo del documento:
Article