Expanding sugar alcohol industry: Microbial production of sugar alcohols and associated chemocatalytic derivatives.
Biotechnol Adv
; 64: 108105, 2023.
Article
en En
| MEDLINE
| ID: mdl-36736865
ABSTRACT
Sugar alcohols are polyols that are widely employed in the production of chemicals, pharmaceuticals, and food products. Chemical synthesis of polyols, however, is complex and necessitates the use of hazardous compounds. Therefore, the use of microbes to produce polyols has been proposed as an alternative to traditional synthesis strategies. Many biotechnological approaches have been described to enhancing sugar alcohols production and microbe-mediated sugar alcohol production has the potential to benefit from the availability of inexpensive substrate inputs. Among of them, microbe-mediated erythritol production has been implemented in an industrial scale, but microbial growth and substrate conversion rates are often limited by harsh environmental conditions. In this review, we focused on xylitol, mannitol, sorbitol, and erythritol, the four representative sugar alcohols. The main metabolic engineering strategies, such as regulation of key genes and cofactor balancing, for improving the production of these sugar alcohols were reviewed. The feasible strategies to enhance the stress tolerance of chassis cells, especially thermotolerance, were also summarized. Different low-cost substrates like glycerol, molasses, cellulose hydrolysate, and CO2 employed for producing these sugar alcohols were presented. Given the value of polyols as precursor platform chemicals that can be leveraged to produce a diverse array of chemical products, we not only discuss the challenges encountered in the above parts, but also envisioned the development of their derivatives for broadening the application of sugar alcohols.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Alcoholes del Azúcar
/
Azúcares
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
Biotechnol Adv
Año:
2023
Tipo del documento:
Article
País de afiliación:
China