An Exercise and Physical Activity Program in Patients With Atrial Fibrillation: The ACTIVE-AF Randomized Controlled Trial.
JACC Clin Electrophysiol
; 9(4): 455-465, 2023 04.
Article
en En
| MEDLINE
| ID: mdl-36752479
ABSTRACT
BACKGROUND:
There are limited data on the effect of exercise interventions on atrial fibrillation (AF) recurrence and symptoms.OBJECTIVES:
The aim of this study was to determine the efficacy of an exercise and physical activity intervention on AF burden and symptoms among patients with symptomatic AF.METHODS:
This prospective, randomized controlled trial included 120 patients with paroxysmal or persistent, symptomatic AF, randomized 11 to receive an exercise intervention, combining home and supervised aerobic exercise over 6 months, or to receive usual care. The coprimary outcomes were 1) AF recurrence, off antiarrhythmic medications and without catheter ablation; and 2) symptom severity assessed by using a validated questionnaire.RESULTS:
By 12 months, freedom from AF was achieved in 24 (40%) of 60 patients in the exercise group and 12 (20%) of 60 patients in the control group (HR 0.50 95% CI 0.33 to 0.78). At 6 months, AF symptom severity was lower in the exercise group compared with the control group (mean difference -2.3; 95% CI -4.3 to -0.2; P = 0.033). This difference persisted at 12 months (-2.3; 95% CI -4.5 to -0.1; P = 0.041). Total symptom burden was lower at 6 months in the exercise group but not at 12 months. Peak oxygen consumption was increased in the exercise group at both 6 and 12 months. There were no between-group differences in cardiac structure or function, body mass index, or blood pressure.CONCLUSIONS:
Participation in an exercise-based intervention over 6 months reduced arrhythmia recurrence and improved symptom severity among patients with AF. (A Lifestyle-based, PhysiCal AcTIVity IntErvention for Patients With Symptomatic Atrial Fibrillation [the ACTIVE-AF Study]; ACTRN12615000734561).Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Fibrilación Atrial
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
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Observational_studies
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Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
JACC Clin Electrophysiol
Año:
2023
Tipo del documento:
Article