Immunosuppressive Bibenzyl-phenylpropane Hybrids from Dendrobium devonianum.
Chem Biodivers
; 20(3): e202201185, 2023 Mar.
Article
en En
| MEDLINE
| ID: mdl-36795028
ABSTRACT
Two new bibenzyl-phenylpropane hybrids, dendrophenols A and B (1 and 2), along with nine known bibenzyls, were isolated from the aerial part of Dendrobium devonianum Paxt. Their structures were determined by extensive spectroscopic methods and methylation. Bioassays revealed that compounds 1-9 were specifically immunosuppressive to T lymphocytes with IC50 values ranging from 0.41 to 9.4â
µM, of which compounds 1 (IC50 =1.62â
µM) and 2 (IC50 =0.41â
µM) were promising immunosuppressive agents for T lymphocytes with the selectivity indices of 19.9 and 79.5, respectively.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Bibencilos
/
Dendrobium
Idioma:
En
Revista:
Chem Biodivers
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2023
Tipo del documento:
Article