Complement receptor C5aR1 blockade reprograms tumor-associated macrophages and synergizes with anti-PD-1 therapy in gastric cancer.

Zhang, Puran; Gu, Yun; Wang, Jieti; Lv, Kunpeng; Lin, Chao; Zhang, Heng; Li, He; He, Hongyong; Li, Ruochen; Liu, Hao; Xu, Jiejie

Zhang, Puran; Gu, Yun; Wang, Jieti; Lv, Kunpeng; Lin, Chao; Zhang, Heng; Li, He; He, Hongyong; Li, Ruochen; Liu, Hao; Xu, Jiejie.

Afiliación

Zhang P; NHC Key Laboratory of Glycoconjugate Research, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Gu Y; NHC Key Laboratory of Glycoconjugate Research, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Wang J; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Lv K; Department of Endoscopy, Fudan University Shanghai Cancer Center, Shanghai, China.
Lin C; NHC Key Laboratory of Glycoconjugate Research, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Zhang H; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Li H; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
He H; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Li R; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Liu H; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Xu J; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Int J Cancer ; 153(1): 224-237, 2023 07 01.

Article en En | MEDLINE | ID: mdl-36799619

Asunto(s)

Receptores de Complemento; Neoplasias Gástricas; Humanos; Linfocitos T CD8-positivos; Macrófagos/metabolismo; Receptores de Complemento/metabolismo; Neoplasias Gástricas/tratamiento farmacológico; Neoplasias Gástricas/metabolismo; Microambiente Tumoral; Macrófagos Asociados a Tumores

Palabras clave

combinatorial treatment; complement receptor C5aR1; gastric cancer; myeloid-checkpoint; tumor-associated macrophages

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Receptores de Complemento Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Int J Cancer Año: 2023 Tipo del documento: Article País de afiliación: China

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