[Current post-surgical treatment strategies in first-line ovarian cancer]. / Stratégies thérapeutiques post-chirurgicales actuelles dans les cancers de l'ovaire en première ligne de traitement.
Bull Cancer
; 111(3): 267-276, 2024 Mar.
Article
en Fr
| MEDLINE
| ID: mdl-36863923
ABSTRACT
Although the management of epithelial ovarian cancer has evolved significantly over the past few years, it remains a public health issue, as most patients are diagnosed at an advanced stage and relapse after first line treatment. Chemotherapy remains the standard adjuvant treatment for International Federation of Gynecology and Obstetrics (FIGO) stage I and II tumors, with some exceptions. For FIGO stage III/IV tumors, carboplatin- and paclitaxel-based chemotherapy are the standard of care, in combination with targeted therapies, especially bevacizumab and/or poly-(ADP-ribose) polymerase inhibitors, that have become a key milestone of first-line treatment. Our decision making for the maintenance therapy is based on the FIGO stage, tumor histology, timing of surgery (i.e. primary or interval debulking surgery), residual tumor, response to chemotherapy, BRCA mutation and homologous recombination (HR) status.
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Texto completo:
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Base de datos:
MEDLINE
Asunto principal:
Neoplasias Ováricas
/
Recurrencia Local de Neoplasia
Límite:
Female
/
Humans
Idioma:
Fr
Revista:
Bull Cancer
Año:
2024
Tipo del documento:
Article