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Alveolar Macrophages-Mediated Translocation of Intratracheally Delivered Perfluorocarbon Nanoparticles to Achieve Lung Cancer 19F-MR Imaging.
Wang, Hongbin; Li, Xiaona; Wang, Jing; Wang, Jiannan; Zou, Hongyan; Hu, Xuesong; Yang, Linqing; Shen, Penghui; A, Rong; Wang, Kaiqi; Li, Yingbo; Yang, Jie; Wang, Kai; Yang, Lili; Wu, Lina; Sun, Xilin.
Afiliación
  • Wang H; Department of Nuclear Medicine, The Fourth Hospital of Harbin Medical University, Harbin 150028, China.
  • Li X; NHC Key Laboratory of Molecular Probe and Targeted Diagnosis and Therapy, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin 150028, China.
  • Wang J; Department of Nuclear Medicine, The Fourth Hospital of Harbin Medical University, Harbin 150028, China.
  • Wang J; NHC Key Laboratory of Molecular Probe and Targeted Diagnosis and Therapy, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin 150028, China.
  • Zou H; Department of Nuclear Medicine, The Fourth Hospital of Harbin Medical University, Harbin 150028, China.
  • Hu X; NHC Key Laboratory of Molecular Probe and Targeted Diagnosis and Therapy, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin 150028, China.
  • Yang L; Department of Nuclear Medicine, The Fourth Hospital of Harbin Medical University, Harbin 150028, China.
  • Shen P; NHC Key Laboratory of Molecular Probe and Targeted Diagnosis and Therapy, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin 150028, China.
  • A R; Department of Nuclear Medicine, The Fourth Hospital of Harbin Medical University, Harbin 150028, China.
  • Wang K; NHC Key Laboratory of Molecular Probe and Targeted Diagnosis and Therapy, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin 150028, China.
  • Li Y; Department of Nuclear Medicine, The Fourth Hospital of Harbin Medical University, Harbin 150028, China.
  • Yang J; NHC Key Laboratory of Molecular Probe and Targeted Diagnosis and Therapy, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin 150028, China.
  • Wang K; Department of Nuclear Medicine, The Fourth Hospital of Harbin Medical University, Harbin 150028, China.
  • Yang L; NHC Key Laboratory of Molecular Probe and Targeted Diagnosis and Therapy, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin 150028, China.
  • Wu L; Department of Nuclear Medicine, The Fourth Hospital of Harbin Medical University, Harbin 150028, China.
  • Sun X; NHC Key Laboratory of Molecular Probe and Targeted Diagnosis and Therapy, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin 150028, China.
Nano Lett ; 23(7): 2964-2973, 2023 04 12.
Article en En | MEDLINE | ID: mdl-36947431
ABSTRACT
Recent advances in intratracheal delivery strategies have sparked considerable biomedical interest in developing this promising approach for lung cancer diagnosis and treatment. However, there are very few relevant studies on the behavior and mechanism of imaging nanoparticles (NPs) after intratracheal delivery. Here, we found that nanosized perfluoro-15-crown-5-ether (PFCE NPs, ∼200 nm) exhibite significant 19F-MRI signal-to-noise ratio (SNR) enhancement than perfluorooctyl bromide (PFOB NPs) up to day 7 after intratracheal delivery. Alveolar macrophages (AMs) engulf PFCE NPs, become PFCE NPs-laden AMs, and then migrate into the tumor margin, resulting in increased tumor PFCE concentration and 19F-MRI signals. AMs-mediated translocation of PFCE NPs to lung draning lymph nodes (dLNs) decreases the background PFCE concentration. Our results shed light on the dynamic AMs-mediated translocation of intratracheally delivered PFC NPs for effective lung tumor visualization and reveal a pathway to develop and promote the clinical translation of an intratracheal delivery-based imaging strategy.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Nanopartículas / Fluorocarburos / Neoplasias Pulmonares Límite: Humans Idioma: En Revista: Nano Lett Año: 2023 Tipo del documento: Article País de afiliación: China
Texto completo
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XML
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Nanopartículas / Fluorocarburos / Neoplasias Pulmonares Límite: Humans Idioma: En Revista: Nano Lett Año: 2023 Tipo del documento: Article País de afiliación: China