Cilostazol novel neuroprotective mechanism against rotenone-induced Parkinson's disease in rats: Correlation between Nrf2 and HMGB1/TLR4/PI3K/Akt/mTOR signaling.

El-Sayed, Rehab M; Abdelaziz, Ahmed M; Zaki, Hala F; Abdel Rasheed, Nora O

El-Sayed, Rehab M; Abdelaziz, Ahmed M; Zaki, Hala F; Abdel Rasheed, Nora O.

Afiliación

El-Sayed RM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Sinai University, El-Arish, Egypt.
Abdelaziz AM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Sinai University, El-Arish, Egypt. Electronic address: ahmed.abdelaziz@su.edu.eg.
Zaki HF; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Abdel Rasheed NO; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Int Immunopharmacol ; 117: 109986, 2023 Apr.

Article en En | MEDLINE | ID: mdl-37012873

Asunto(s)

Proteína HMGB1; Fármacos Neuroprotectores; Enfermedad de Parkinson; Ratas; Animales; Proteínas Proto-Oncogénicas c-akt/metabolismo; Rotenona; Cilostazol/uso terapéutico; Fosfatidilinositol 3-Quinasa; Fosfatidilinositol 3-Quinasas/metabolismo; Enfermedad de Parkinson/tratamiento farmacológico; Factor 2 Relacionado con NF-E2/metabolismo; Receptor Toll-Like 4; Neuroprotección; Serina-Treonina Quinasas TOR/metabolismo; Fármacos Neuroprotectores/farmacología; Fármacos Neuroprotectores/uso terapéutico; Mamíferos

Palabras clave

Cilostazol; HMGB1/TLR4; Nrf2/HO-1; PI3K/Akt/mTOR; Parkinson's disease; Rotenone

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Fármacos Neuroprotectores / Proteína HMGB1 Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Int Immunopharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Egipto

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