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Bifunctional degraders of cyclin dependent kinase 9 (CDK9): Probing the relationship between linker length, properties, and selective protein degradation.
Tokarski, Robert J; Sharpe, Chia M; Huntsman, Andrew C; Mize, Brittney K; Ayinde, Oluwatosin R; Stahl, Emily H; Lerma, James R; Reed, Andrew; Carmichael, Bridget; Muthusamy, Natarajan; Byrd, John C; Fuchs, James R.
Afiliación
  • Tokarski RJ; Division of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, United States.
  • Sharpe CM; Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, 45267, United States.
  • Huntsman AC; Division of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, United States.
  • Mize BK; Division of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, United States.
  • Ayinde OR; Division of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, United States.
  • Stahl EH; The Ohio State University Comprehensive Cancer Center, College of Medicine, The Ohio State University, Columbus, OH, 43210, United States.
  • Lerma JR; Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, 45267, United States.
  • Reed A; CCIC Mass Spectrometry and Proteomics, The Ohio State University, Columbus, OH, 43210, United States.
  • Carmichael B; The Ohio State University Comprehensive Cancer Center, College of Medicine, The Ohio State University, Columbus, OH, 43210, United States.
  • Muthusamy N; The Ohio State University Comprehensive Cancer Center, College of Medicine, The Ohio State University, Columbus, OH, 43210, United States.
  • Byrd JC; Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, 45267, United States; University of Cincinnati Cancer Center, College of Medicine, University of Cincinnati, Cincinnati, OH, 45267, United States.
  • Fuchs JR; Division of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, United States. Electronic address: fuchs.42@osu.edu.
Eur J Med Chem ; 254: 115342, 2023 Jun 05.
Article en En | MEDLINE | ID: mdl-37071962
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Quinasa 9 Dependiente de la Ciclina Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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PubMed Links
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Quinasa 9 Dependiente de la Ciclina Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos