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First-in-class multifunctional TYMS nonclassical antifolate inhibitor with potent in vivo activity that prolongs survival.
Guijarro, Maria V; Kellish, Patrick C; Dib, Peter E; Paciaroni, Nicholas G; Nawab, Akbar; Andring, Jacob; Kulemina, Lidia; Borrero, Nicholas V; Modenutti, Carlos; Feely, Michael; Nasri, Elham; Seifert, Robert P; Luo, Xiaoping; Bennett, Richard L; Shabashvili, Daniil; Licht, Jonathan D; McKenna, Robert; Roitberg, Adrian; Huigens, Robert W; Kaye, Frederic J; Zajac-Kaye, Maria.
Afiliación
  • Guijarro MV; Department of Anatomy and Cell Biology.
  • Kellish PC; Department of Anatomy and Cell Biology.
  • Dib PE; Department of Anatomy and Cell Biology.
  • Paciaroni NG; Department of Medicinal Chemistry, and.
  • Nawab A; Department of Anatomy and Cell Biology.
  • Andring J; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USA.
  • Kulemina L; Department of Anatomy and Cell Biology.
  • Borrero NV; Department of Medicinal Chemistry, and.
  • Modenutti C; Department of Biological Chemistry, Faculty of Exact and Natural Sciences, University of Buenos Aires, and.
  • Feely M; Institute of Biological Chemistry of the Faculty of Exact and Natural Sciences (IQUIBICEN) CONICET, University City, Pab. II (CE1428EHA), Buenos Aires, Argentina.
  • Nasri E; Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.
  • Seifert RP; Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.
  • Luo X; Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.
  • Bennett RL; Department of Anatomy and Cell Biology.
  • Shabashvili D; Department of Medicine, University of Florida Health Cancer Center, Gainesville, Florida, USA.
  • Licht JD; Department of Anatomy and Cell Biology.
  • McKenna R; Department of Medicine, University of Florida Health Cancer Center, Gainesville, Florida, USA.
  • Roitberg A; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USA.
  • Huigens RW; Department of Chemistry, University of Florida, Gainesville, Florida, USA.
  • Kaye FJ; Department of Medicinal Chemistry, and.
  • Zajac-Kaye M; Department of Medicine, University of Florida Health Cancer Center, Gainesville, Florida, USA.
JCI Insight ; 8(10)2023 04 25.
Article en En | MEDLINE | ID: mdl-37097751
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Antagonistas del Ácido Fólico Límite: Animals / Humans Idioma: En Revista: JCI Insight Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Antagonistas del Ácido Fólico Límite: Animals / Humans Idioma: En Revista: JCI Insight Año: 2023 Tipo del documento: Article