[Clinical significance of multigene assay in papillary thyroid carcinoma].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
; 37(5): 375-379, 2023 May.
Article
en Zh
| MEDLINE
| ID: mdl-37138401
ABSTRACT
Objective:
To analyze the clinical significance of multigene assay in papillary thyroid carcinomaï¼PTCï¼.Methods:
Patients who underwent thyroidectomy in a tertiary hospital from August 2021 to May 2022 were enrolled. The eight-gene panel was used to detect the tumor tissue of patients, and the correlation between gene mutations and clinical features was analyzed.Results:
Among 161 patients, mutation rate of BRAF V600E, RET/PTC1 and TERT promotor were 82.0%, 6.8% and 4.3%, respectively. BRAF V600E mutation was more common in male patientsï¼P=0.023ï¼. TERT promotor-mutated tumors had a large diameterï¼P=0.019ï¼, a high proportion of multifocal lesionsï¼P=0.050ï¼, and a large number of lymph node metastasesï¼P=0.031ï¼. Among 89 patients who completed preoperative BRAF detection, there was a strong consistency between the preoperative aspiration test and postoperative panelï¼Cohen κ=0.694, 95%CI 0.482-0.906, P<0.01ï¼. In the hematoxylin-eosin sections obtained from 80 patients, BRAF V600E was still the main type of gene mutation, and the classical/follicular type was more distributed. TERT promotor and RET/PTC1 mutation were the main genetic events for tall-cell/columnar/hobnail type and diffuse sclerosing type, respectively. One-way ANOVA showed that there were differences in diagnosis ageï¼P=0.029ï¼ and tumor sizeï¼P<0.01ï¼ among different pathological types.Conclusion:
As a simple and feasible clinical detection method for PTC, the multigene assay can supplement the identification of important genetic events other than BRAF V600E, and provide more prognostic information and follow-up hints for postoperative patients.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Tiroides
/
Carcinoma Papilar
Tipo de estudio:
Prognostic_studies
Límite:
Humans
/
Male
Idioma:
Zh
Revista:
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
Año:
2023
Tipo del documento:
Article