Brain Features of Treatment-Resistant Depression: A Review of Structural and Functional Connectivity Magnetic Resonance Imaging Studies.
Psychiatr Clin North Am
; 46(2): 391-401, 2023 06.
Article
en En
| MEDLINE
| ID: mdl-37149352
ABSTRACT
Increased awareness of the growing disease burden of treatment resistant depression (TRD), in combination with technological advances in MRI, affords the unique opportunity to research biomarkers that characterize TRD. We provide a narrative review of MRI studies investigating brain features associated with treatment-resistance and treatment outcome in those with TRD. Despite heterogeneity in methods and outcomes, relatively consistent findings include reduced gray matter volume in cortical regions and reduced white matter structural integrity in those with TRD. Alterations in resting state functional connectivity of the default mode network were also found. Larger studies with prospective designs are warranted.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Trastorno Depresivo Resistente al Tratamiento
Límite:
Humans
Idioma:
En
Revista:
Psychiatr Clin North Am
Año:
2023
Tipo del documento:
Article