Conformation and Affinity Modulations by Multiple Phosphorylation Occurring in the BIN1 SH3 Domain Binding Site of the Tau Protein Proline-Rich Region.

Lasorsa, Alessia; Bera, Krishnendu; Malki, Idir; Dupré, Elian; Cantrelle, François-Xavier; Merzougui, Hamida; Sinnaeve, Davy; Hanoulle, Xavier; Hritz, Jozef; Landrieu, Isabelle

Lasorsa, Alessia; Bera, Krishnendu; Malki, Idir; Dupré, Elian; Cantrelle, François-Xavier; Merzougui, Hamida; Sinnaeve, Davy; Hanoulle, Xavier; Hritz, Jozef; Landrieu, Isabelle.

Afiliación

Lasorsa A; CNRS EMR9002 Integrative Structural Biology, Lille F-59000, France.
Bera K; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille F-59000, France.
Malki I; CEITEC MU, Masaryk University, Kamenice 753/5, Brno 625 00, Czech Republic.
Dupré E; National Centre for Biomolecular Research, Faculty of Science, Masaryk University, Kamenice 5, Brno 625 00, Czech Republic.
Cantrelle FX; Department of Chemistry, Faculty of Science, Masaryk University, Kamenice 5, Brno 625 00, Czech Republic.
Merzougui H; CNRS EMR9002 Integrative Structural Biology, Lille F-59000, France.
Sinnaeve D; CNRS EMR9002 Integrative Structural Biology, Lille F-59000, France.
Hanoulle X; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille F-59000, France.
Hritz J; CNRS EMR9002 Integrative Structural Biology, Lille F-59000, France.
Landrieu I; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille F-59000, France.

Biochemistry ; 62(11): 1631-1642, 2023 06 06.

Article en En | MEDLINE | ID: mdl-37167199

Asunto(s)

Enfermedad de Alzheimer; Proteínas tau; Humanos; Proteínas tau/metabolismo; Fosforilación; Dominios Homologos src; Unión Proteica; Enfermedad de Alzheimer/metabolismo; Péptidos/química; Sitios de Unión; Prolina/metabolismo; Proteínas Nucleares/metabolismo; Proteínas Supresoras de Tumor/química; Proteínas Adaptadoras Transductoras de Señales/metabolismo

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteínas tau / Enfermedad de Alzheimer Límite: Humans Idioma: En Revista: Biochemistry Año: 2023 Tipo del documento: Article País de afiliación: Francia

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