The extent of damage to the blood-brain barrier in the hypercholesterolemic LDLR<sup>-/-</sup>/Apo E<sup>-/-</sup> double knockout mice depends on the animal's age, duration of pathology and brain area.

Czuba-Pakula, Ewelina; Glowinski, Sebastian; Wójcik, Slawomir; Lietzau, Grazyna; Zabielska-Kaczorowska, Magdalena; Kowianski, Przemyslaw

The extent of damage to the blood-brain barrier in the hypercholesterolemic LDLR^-/-/Apo E^-/- double knockout mice depends on the animal's age, duration of pathology and brain area.

Czuba-Pakula, Ewelina; Glowinski, Sebastian; Wójcik, Slawomir; Lietzau, Grazyna; Zabielska-Kaczorowska, Magdalena; Kowianski, Przemyslaw.

Afiliación

Czuba-Pakula E; Division of Anatomy and Neurobiology, Faculty of Medicine, Medical University of Gdansk, Debinki 1, 80-211 Gdansk, Poland. Electronic address: ewelina.czuba@gumed.edu.pl.
Glowinski S; Institute of Health Sciences, Pomeranian University in Slupsk, Bohaterów Westerplatte 64, 76-200 Slupsk, Poland. Electronic address: sebastian.glowinski@tu.koszalin.pl.
Wójcik S; Division of Anatomy and Neurobiology, Faculty of Medicine, Medical University of Gdansk, Debinki 1, 80-211 Gdansk, Poland. Electronic address: slawomir.wojcik@gumed.edu.pl.
Lietzau G; Division of Anatomy and Neurobiology, Faculty of Medicine, Medical University of Gdansk, Debinki 1, 80-211 Gdansk, Poland. Electronic address: grazyna.lietzau@gumed.edu.pl.
Zabielska-Kaczorowska M; Department of Physiology, Medical University of Gdansk, Debinki 1, 80-211 Gdansk, Poland; Department of Biochemistry, Medical University of Gdansk, Debinki 1, 80-211 Gdansk, Poland. Electronic address: magdalena.zabielska-kaczorowska@gumed.edu.pl.
Kowianski P; Division of Anatomy and Neurobiology, Faculty of Medicine, Medical University of Gdansk, Debinki 1, 80-211 Gdansk, Poland; Institute of Health Sciences, Pomeranian University in Slupsk, Bohaterów Westerplatte 64, 76-200 Slupsk, Poland. Electronic address: przemyslaw.kowianski@gumed.edu.pl.

Mol Cell Neurosci ; 125: 103860, 2023 06.

Article en En | MEDLINE | ID: mdl-37182573

Asunto(s)

Barrera Hematoencefálica; Encéfalo; Animales; Masculino; Ratones; Apolipoproteínas E/metabolismo; Barrera Hematoencefálica/metabolismo; Encéfalo/metabolismo; Ratones Endogámicos C57BL; Ratones Noqueados; Receptores de LDL/metabolismo

Palabras clave

Agrin; Aquaporin-4; Blood-brain barrier; Hypercholesterolemia; Matrix metallopeptidase-9; Neurovascular unit

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Encéfalo / Barrera Hematoencefálica Límite: Animals Idioma: En Revista: Mol Cell Neurosci Asunto de la revista: BIOLOGIA MOLECULAR / NEUROLOGIA Año: 2023 Tipo del documento: Article

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