Antigen-specific and cross-reactive T cells in protection and disease.
Immunol Rev
; 316(1): 120-135, 2023 07.
Article
en En
| MEDLINE
| ID: mdl-37209375
ABSTRACT
Human T cells have a diverse T-cell receptor (TCR) repertoire that endows them with the ability to identify and defend against a broad spectrum of antigens. The universe of possible antigens that T cells may encounter, however, is even larger. To effectively surveil such a vast universe, the T-cell repertoire must adopt a high degree of cross-reactivity. Likewise, antigen-specific and cross-reactive T-cell responses play pivotal roles in both protective and pathological immune responses in numerous diseases. In this review, we explore the implications of these antigen-driven T-cell responses, with a particular focus on CD8+ T cells, using infection, neurodegeneration, and cancer as examples. We also summarize recent technological advances that facilitate high-throughput profiling of antigen-specific and cross-reactive T-cell responses experimentally, as well as computational biology approaches that predict these interactions.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Linfocitos T CD8-positivos
/
Antígenos
Límite:
Humans
Idioma:
En
Revista:
Immunol Rev
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos