Application prospect of low-dose porcine anti-thymocyte globulin in HLA-matched sibling donor transplantation.
Hematology
; 28(1): 2212943, 2023 Dec.
Article
en En
| MEDLINE
| ID: mdl-37219061
ABSTRACT
OBJECTIVE:
To investigate the preventive effect of low-dose porcine anti-thymocyte globulin (P-ATG) on graft versus host disease (GVHD) in patients' donors over 40 years old or female donors undergoing HLA-matched sibling donor hematopoietic stem cell transplantation (MSD-HSCT).METHODS:
The clinical data of 30 patients received Low-dose Porcine antithymocyte globulin (P-ATG) as a part of the conditioning regimen (the P-ATG group), while the other 30 patients didn't receive ATG (the Non-ATG group).RESULTS:
There was a significant difference in the incidence of aGVHD ([23.3 (10.1-39.7) %] vs [50.0 (30.8-66.5) %], P = 0.028), grade II-IV aGVHD ([16.7 (5.94-32.1) %] vs [40.0 (22.4-57.0) %], P = 0.049) and chronic GVHD (cGVHD) ([22.4 (6.03-45.1) %] vs [69.0 (43.4-84.8) %], P = 0.001) between two groups. But there was no significant difference in terms of moderate-severe cGVHD (P = 0.129), 1-year relapse rate (P = 0.742), non-relapse mortality (P = 0.237), or overall survival (P = 0.441).CONCLUSION:
The application of low-dose P-ATG in patients/donors over 40 years old or female donors undergoing MSD-HSCT for hematological malignancy can significantly reduce the incidence of aGVHD, grade II-IV aGVHD and cGVHD, doesn't increase the risk of relapse.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Trasplante de Células Madre Hematopoyéticas
/
Enfermedad Injerto contra Huésped
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Animals
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Female
/
Humans
Idioma:
En
Revista:
Hematology
Asunto de la revista:
HEMATOLOGIA
Año:
2023
Tipo del documento:
Article