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Robust and prototypical immune responses toward COVID-19 vaccine in First Nations peoples are impacted by comorbidities.
Zhang, Wuji; Kedzierski, Lukasz; Chua, Brendon Y; Mayo, Mark; Lonzi, Claire; Rigas, Vanessa; Middleton, Bianca F; McQuilten, Hayley A; Rowntree, Louise C; Allen, Lilith F; Purcell, Ruth A; Tan, Hyon-Xhi; Petersen, Jan; Chaurasia, Priyanka; Mordant, Francesca; Pogorelyy, Mikhail V; Minervina, Anastasia A; Crawford, Jeremy Chase; Perkins, Griffith B; Zhang, Eva; Gras, Stephanie; Clemens, E Bridie; Juno, Jennifer A; Audsley, Jennifer; Khoury, David S; Holmes, Natasha E; Thevarajan, Irani; Subbarao, Kanta; Krammer, Florian; Cheng, Allen C; Davenport, Miles P; Grubor-Bauk, Branka; Coates, P Toby; Christensen, Britt; Thomas, Paul G; Wheatley, Adam K; Kent, Stephen J; Rossjohn, Jamie; Chung, Amy W; Boffa, John; Miller, Adrian; Lynar, Sarah; Nelson, Jane; Nguyen, Thi H O; Davies, Jane; Kedzierska, Katherine.
Afiliación
  • Zhang W; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
  • Kedzierski L; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
  • Chua BY; Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Melbourne, Victoria, Australia.
  • Mayo M; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
  • Lonzi C; Menzies School of Health Research, Darwin, Northern Territory, Australia.
  • Rigas V; Menzies School of Health Research, Darwin, Northern Territory, Australia.
  • Middleton BF; Menzies School of Health Research, Darwin, Northern Territory, Australia.
  • McQuilten HA; Menzies School of Health Research, Darwin, Northern Territory, Australia.
  • Rowntree LC; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
  • Allen LF; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
  • Purcell RA; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
  • Tan HX; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
  • Petersen J; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
  • Chaurasia P; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
  • Mordant F; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
  • Pogorelyy MV; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
  • Minervina AA; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Crawford JC; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Perkins GB; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Zhang E; Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
  • Gras S; Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
  • Clemens EB; Department of Gastroenterology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
  • Juno JA; Macquarie University, Sydney, New South Wales, Australia.
  • Audsley J; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
  • Khoury DS; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria, Australia.
  • Holmes NE; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
  • Thevarajan I; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
  • Subbarao K; Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, University of Melbourne and Royal Melbourne Hospital, Melbourne, Victoria, Australia.
  • Krammer F; Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
  • Cheng AC; Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia.
  • Davenport MP; Department of Infectious Diseases, Peter Doherty Institute for Infection and Immunity, University of Melbourne and Royal Melbourne Hospital, Melbourne, Victoria, Australia.
  • Grubor-Bauk B; Victorian Infectious Diseases Services, Royal Melbourne Hospital and Doherty Department, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
  • Coates PT; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
  • Christensen B; World Health Organization Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
  • Thomas PG; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Wheatley AK; Department of Infectious Diseases, Alfred Hospital and Central Clinical School and School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
  • Kent SJ; Monash Infectious Diseases, Monash Health and School of Clinical Sciences, Monash University, Melbourne, Victoria, Australia.
  • Rossjohn J; Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
  • Chung AW; Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
  • Boffa J; Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
  • Miller A; Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
  • Lynar S; Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
  • Nelson J; Department of Medicine, University of Melbourne, Parkville, Victoria, Australia.
  • Nguyen THO; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
  • Davies J; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
  • Kedzierska K; Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia.
Nat Immunol ; 24(6): 966-978, 2023 06.
Article en En | MEDLINE | ID: mdl-37248417
ABSTRACT
High-risk groups, including Indigenous people, are at risk of severe COVID-19. Here we found that Australian First Nations peoples elicit effective immune responses to COVID-19 BNT162b2 vaccination, including neutralizing antibodies, receptor-binding domain (RBD) antibodies, SARS-CoV-2 spike-specific B cells, and CD4+ and CD8+ T cells. In First Nations participants, RBD IgG antibody titers were correlated with body mass index and negatively correlated with age. Reduced RBD antibodies, spike-specific B cells and follicular helper T cells were found in vaccinated participants with chronic conditions (diabetes, renal disease) and were strongly associated with altered glycosylation of IgG and increased interleukin-18 levels in the plasma. These immune perturbations were also found in non-Indigenous people with comorbidities, indicating that they were related to comorbidities rather than ethnicity. However, our study is of a great importance to First Nations peoples who have disproportionate rates of chronic comorbidities and provides evidence of robust immune responses after COVID-19 vaccination in Indigenous people.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Vacunas contra la COVID-19 / COVID-19 Límite: Humans País/Región como asunto: Oceania Idioma: En Revista: Nat Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Australia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Vacunas contra la COVID-19 / COVID-19 Límite: Humans País/Región como asunto: Oceania Idioma: En Revista: Nat Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Australia