Fatty acid composition of cholesterol esters reflects dietary fat intake after dietary interventions in a multinational population.
J Clin Lipidol
; 17(4): 466-474, 2023.
Article
en En
| MEDLINE
| ID: mdl-37263854
ABSTRACT
BACKGROUND:
The effects of different dietary fatty acids (FA) on cardiovascular risk still needs clarification. Plasma lipids composition may be a biomarker of FA dietary intake.PURPOSE:
To evaluate in a composite population the relationships between changes in dietary fat intake and changes in FA levels in serum cholesterol esters.METHODS:
In a multinational, parallel-design, dietary intervention (KANWU study), dietary intakes (3-day food record) and FA composition of serum cholesterol esters (gas-liquid chromatography) were evaluated at baseline and after 3 months in 162 healthy individuals, randomly assigned to a diet containing a high proportion of saturated (SFA) or monounsaturated (MUFA) fat, with a second random assignment to fish oil or placebo supplements.RESULTS:
Main differences in serum lipid composition after the two diets included saturated (especially myristic, C140, and pentadecanoic, C150) and monounsaturated (oleic acid, C181 n-9) FA. C140 and C150 were related to SFA intake, while C181 n-9 was associated with MUFA intake. Fish oil supplementation induced a marked increase in eicosapentaenoic (C205 n-3) and docosahexaenoic (C226 n-3) acids. After the 3-month intervention, Δ-9 desaturase activity, calculated as palmitoleic acid/palmitic acid (C161/C160) ratio, was more reduced after the MUFA (0.31±0.10 vs 0.25±0.09, p<0.0001) than SFA diet (0.31±0.09 vs 0.29±0.08, p=0.006), with a statistically significant difference between the two groups (p<0.0001).CONCLUSIONS:
This study shows that serum cholesterol ester FA composition can be used during randomized controlled trials as an objective indicator of adherence to experimental diets based on saturated and monounsaturated fat modifications, as well as fish oil supplementation.Palabras clave
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Base de datos:
MEDLINE
Asunto principal:
Ésteres del Colesterol
/
Ácidos Grasos
Tipo de estudio:
Clinical_trials
Límite:
Humans
Idioma:
En
Revista:
J Clin Lipidol
Asunto de la revista:
BIOQUIMICA
/
METABOLISMO
Año:
2023
Tipo del documento:
Article
País de afiliación:
Italia