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A novel approach for pharmacological substantiation of safety signals using plasma concentrations of medication and administrative/healthcare databases: A case study using Danish registries for an FDA warning on lamotrigine.
Wang, Wenyi; Battini, Vera; Carnovale, Carla; Noordam, Raymond; van Dijk, Ko Willems; Kragholm, Kristian Hay; van Heemst, Diana; Soeorg, Hiie; Sessa, Maurizio.
Afiliación
  • Wang W; Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands; Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
  • Battini V; Department of Biomedical and Clinical Sciences, Università degli Studi di Milano, Italy; Department of Drug Design and Pharmacology, University of Copenhagen, Denmark.
  • Carnovale C; Department of Biomedical and Clinical Sciences, Università degli Studi di Milano, Italy.
  • Noordam R; Department of Internal Medicine, Section of Gerontology and Geriatrics; Leiden University Medical Center, Leiden, Netherlands.
  • van Dijk KW; Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands; Department of Internal Medicine, Division Endocrinology, Leiden University Medical Center, Leiden, Netherlands; Leiden Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherl
  • Kragholm KH; Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
  • van Heemst D; Department of Internal Medicine, Section of Gerontology and Geriatrics; Leiden University Medical Center, Leiden, Netherlands.
  • Soeorg H; Department of Microbiology, Institute of Biomedicine and Translational Medicine, Faculty of Medicine, University of Tartu, Estonia. Electronic address: hiie.soeorg@ut.ee.
  • Sessa M; Department of Drug Design and Pharmacology, University of Copenhagen, Denmark. Electronic address: maurizio.sessa@sund.ku.dk.
Pharmacol Res ; 193: 106811, 2023 07.
Article en En | MEDLINE | ID: mdl-37268178
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Triazinas / Anticonvulsivantes Tipo de estudio: Prognostic_studies Límite: Aged / Humans País/Región como asunto: America do norte / Europa Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Dinamarca
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Triazinas / Anticonvulsivantes Tipo de estudio: Prognostic_studies Límite: Aged / Humans País/Región como asunto: America do norte / Europa Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Dinamarca