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Neuroendocrine mechanism of gastric acid secretion: Historical perspectives and recent developments in physiology and pharmacology.
Chen, Duan; Hagen, Susan J; Boyce, Malcolm; Zhao, Chun-Mei.
Afiliación
  • Chen D; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
  • Hagen SJ; Department of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.
  • Boyce M; Hammersmith Medicines Research Ltd, London, UK.
  • Zhao CM; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
J Neuroendocrinol ; 35(11): e13305, 2023 11.
Article en En | MEDLINE | ID: mdl-37317882
ABSTRACT
The physiology of gastric acid secretion is one of the earliest subjects in medical literature and has been continuously studied since 1833. Starting with the notion that neural stimulation alone drives acid secretion, progress in understanding the physiology and pathophysiology of this process has led to the development of therapeutic strategies for patients with acid-related diseases. For instance, understanding the physiology of parietal cells led to the developments of histamine 2 receptor blockers, proton pump inhibitors (PPIs), and recently, potassium-competitive acid blockers. Furthermore, understanding the physiology and pathophysiology of gastrin has led to the development of gastrin/CCK2 receptor (CCK2 R) antagonists. The need for refinement of existing drugs in patients have led to second and third generation drugs with better efficacy at blocking acid secretion. Further understanding of the mechanism of acid secretion by gene targeting in mice has enabled us to dissect the unique role for each regulator to leverage and justify the development of new targeted therapeutics for acid-related disorders. Further research on the mechanism of stimulation of gastric acid secretion and the physiological significances of gastric acidity in gut microbiome is needed in the future.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Gastrinas / Ácido Gástrico Límite: Animals / Humans Idioma: En Revista: J Neuroendocrinol Asunto de la revista: ENDOCRINOLOGIA / NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Noruega

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Gastrinas / Ácido Gástrico Límite: Animals / Humans Idioma: En Revista: J Neuroendocrinol Asunto de la revista: ENDOCRINOLOGIA / NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Noruega