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Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure.
Rasooly, Danielle; Peloso, Gina M; Pereira, Alexandre C; Dashti, Hesam; Giambartolomei, Claudia; Wheeler, Eleanor; Aung, Nay; Ferolito, Brian R; Pietzner, Maik; Farber-Eger, Eric H; Wells, Quinn Stanton; Kosik, Nicole M; Gaziano, Liam; Posner, Daniel C; Bento, A Patrícia; Hui, Qin; Liu, Chang; Aragam, Krishna; Wang, Zeyuan; Charest, Brian; Huffman, Jennifer E; Wilson, Peter W F; Phillips, Lawrence S; Whittaker, John; Munroe, Patricia B; Petersen, Steffen E; Cho, Kelly; Leach, Andrew R; Magariños, María Paula; Gaziano, John Michael; Langenberg, Claudia; Sun, Yan V; Joseph, Jacob; Casas, Juan P.
Afiliación
  • Rasooly D; Division of Aging, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA, 02130, USA. drasooly@bwh.harvard.edu.
  • Peloso GM; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150. S. Huntington Ave, Boston, MA, 02130, USA. drasooly@bwh.harvard.edu.
  • Pereira AC; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150. S. Huntington Ave, Boston, MA, 02130, USA.
  • Dashti H; Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Ave Crosstown Centre, Boston, MA, 02118, USA.
  • Giambartolomei C; Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo, Av Dr Eneas de Carvalho Aguiar 54, São Paulo, 5403000, Brazil.
  • Wheeler E; Genetics Department, Harvard Medical School, Harvard University, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA.
  • Aung N; Division of Aging, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA, 02130, USA.
  • Ferolito BR; Broad Institute of MIT and Harvard, 415 Main St., Cambridge, MA, 02142, USA.
  • Pietzner M; Health Data Science Centre, Human Technopole, V.le Rita Levi-Montalcini, 1, Milan, 20157, Italy.
  • Farber-Eger EH; Central RNA Lab, Non-coding RNAs and RNA-based Therapeutics, Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genova, Italy.
  • Wells QS; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Addenbrookes Hospital, IMS, Box 285, Cambridge, CB2 0QQ, UK.
  • Kosik NM; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
  • Gaziano L; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, West Smithfield, London, UK.
  • Posner DC; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150. S. Huntington Ave, Boston, MA, 02130, USA.
  • Bento AP; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Addenbrookes Hospital, IMS, Box 285, Cambridge, CB2 0QQ, UK.
  • Hui Q; Computational Medicine, Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Kapelle Ufer 2, Berlin, 10117, Germany.
  • Liu C; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK.
  • Aragam K; Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Wang Z; Vanderbilt University Med. Ctr., Departments of Medicine (Cardiology), Biomedical Informatics, and Pharmacology, Nashville, TN, USA.
  • Charest B; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150. S. Huntington Ave, Boston, MA, 02130, USA.
  • Huffman JE; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150. S. Huntington Ave, Boston, MA, 02130, USA.
  • Wilson PWF; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Worts Causeway, Cambridge, CB1 8RN, UK.
  • Phillips LS; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150. S. Huntington Ave, Boston, MA, 02130, USA.
  • Whittaker J; Department of Chemical Biology, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, CB10 1SD, UK.
  • Munroe PB; Department of Epidemiology, Emory University Rollins School of Public Health, 1518 Clifton Rd NE, Atlanta, GA, 30322, USA.
  • Petersen SE; Atlanta VA Health Care System, 1670 Clairmont Road, Decatur, GA, 30033, USA.
  • Cho K; Department of Epidemiology, Emory University Rollins School of Public Health, 1518 Clifton Rd NE, Atlanta, GA, 30322, USA.
  • Leach AR; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150. S. Huntington Ave, Boston, MA, 02130, USA.
  • Magariños MP; Broad Institute of MIT and Harvard, 415 Main St., Cambridge, MA, 02142, USA.
  • Gaziano JM; Massachusetts General Hospital, Boston, MA, 02114, USA.
  • Langenberg C; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150. S. Huntington Ave, Boston, MA, 02130, USA.
  • Sun YV; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150. S. Huntington Ave, Boston, MA, 02130, USA.
  • Joseph J; Atlanta VA Health Care System, 1670 Clairmont Road, Decatur, GA, 30033, USA.
  • Casas JP; Division of Cardiology, Department of Medicine, Emory University School of Medicine, 1639 Pierce Dr NE, Atlanta, GA, 30322, USA.
Nat Commun ; 14(1): 3826, 2023 07 10.
Article en En | MEDLINE | ID: mdl-37429843
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Estudio de Asociación del Genoma Completo / Insuficiencia Cardíaca Tipo de estudio: Clinical_trials / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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PubMed Links
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Estudio de Asociación del Genoma Completo / Insuficiencia Cardíaca Tipo de estudio: Clinical_trials / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos