Hypoxia-reprogramed megamitochondrion contacts and engulfs lysosome to mediate mitochondrial self-digestion.

Hao, Tianshu; Yu, Jianglong; Wu, Zhida; Jiang, Jie; Gong, Longlong; Wang, Bingjun; Guo, Hanze; Zhao, Huabin; Lu, Bin; Engelender, Simone; He, He; Song, Zhiyin

Hao, Tianshu; Yu, Jianglong; Wu, Zhida; Jiang, Jie; Gong, Longlong; Wang, Bingjun; Guo, Hanze; Zhao, Huabin; Lu, Bin; Engelender, Simone; He, He; Song, Zhiyin.

Afiliación

Hao T; College of Life Sciences, Taikang center for life and medical sciences, Frontier Science Center for Immunology and Metabolism, Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, 430072, Hubei, China.
Yu J; College of Life Sciences, Taikang center for life and medical sciences, Frontier Science Center for Immunology and Metabolism, Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, 430072, Hubei, China.
Wu Z; College of Life Sciences, Taikang center for life and medical sciences, Frontier Science Center for Immunology and Metabolism, Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, 430072, Hubei, China.
Jiang J; College of Life Sciences, Taikang center for life and medical sciences, Frontier Science Center for Immunology and Metabolism, Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, 430072, Hubei, China.
Gong L; College of Life Sciences, Taikang center for life and medical sciences, Frontier Science Center for Immunology and Metabolism, Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, 430072, Hubei, China.
Wang B; College of Life Sciences, Taikang center for life and medical sciences, Frontier Science Center for Immunology and Metabolism, Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, 430072, Hubei, China.
Guo H; College of Life Sciences, Taikang center for life and medical sciences, Frontier Science Center for Immunology and Metabolism, Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, 430072, Hubei, China.
Zhao H; College of Life Sciences, Taikang center for life and medical sciences, Frontier Science Center for Immunology and Metabolism, Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, 430072, Hubei, China.
Lu B; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Engelender S; Department of Biochemistry, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
He H; College of Life Sciences, Taikang center for life and medical sciences, Frontier Science Center for Immunology and Metabolism, Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, 430072, Hubei, China. hehe2013@whu.edu.cn.
Song Z; College of Life Sciences, Taikang center for life and medical sciences, Frontier Science Center for Immunology and Metabolism, Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, 430072, Hubei, China. songzy@whu.edu.cn.

Nat Commun ; 14(1): 4105, 2023 07 11.

Article en En | MEDLINE | ID: mdl-37433770

Asunto(s)

Lisosomas; Mitocondrias; Humanos; Hipoxia; Oxígeno; Digestión

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Lisosomas / Mitocondrias Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: China

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