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Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies.
Yang, Xue; Wang, Ying; Rovella, Valentina; Candi, Eleonora; Jia, Wei; Bernassola, Francesca; Bove, Pierluigi; Piacentini, Mauro; Scimeca, Manuel; Sica, Giuseppe; Tisone, Giuseppe; Mauriello, Alessandro; Wei, Lixin; Melino, Gerry; Shi, Yufang.
Afiliación
  • Yang X; Department of Experimental Medicine, TOR, University of Rome Tor Vergata, Rome, 00133, Italy.
  • Wang Y; The Third Affiliated Hospital of Soochow University, Institutes for Translational Medicine, State Key Laboratory of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, Jiangsu, China.
  • Rovella V; The Third Affiliated Hospital of Soochow University, Institutes for Translational Medicine, State Key Laboratory of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, Jiangsu, China.
  • Candi E; Department of Experimental Medicine, TOR, University of Rome Tor Vergata, Rome, 00133, Italy.
  • Jia W; Department of Experimental Medicine, TOR, University of Rome Tor Vergata, Rome, 00133, Italy.
  • Bernassola F; Center for Translational Medicine, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China.
  • Bove P; School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
  • Piacentini M; Department of Experimental Medicine, TOR, University of Rome Tor Vergata, Rome, 00133, Italy.
  • Scimeca M; Department of Experimental Medicine, TOR, University of Rome Tor Vergata, Rome, 00133, Italy.
  • Sica G; Department of Experimental Medicine, TOR, University of Rome Tor Vergata, Rome, 00133, Italy.
  • Tisone G; Department of Experimental Medicine, TOR, University of Rome Tor Vergata, Rome, 00133, Italy.
  • Mauriello A; Department of Experimental Medicine, TOR, University of Rome Tor Vergata, Rome, 00133, Italy.
  • Wei L; Department of Experimental Medicine, TOR, University of Rome Tor Vergata, Rome, 00133, Italy.
  • Melino G; Department of Experimental Medicine, TOR, University of Rome Tor Vergata, Rome, 00133, Italy.
  • Shi Y; Department of Tumor Immunology and Gene Therapy Center, Third Affiliated Hospital of Naval Medical University, Shanghai, 200438, China.
Biol Direct ; 18(1): 40, 2023 07 18.
Article en En | MEDLINE | ID: mdl-37464416
ABSTRACT
Natural ageing of organisms and corresponding age-related diseases result mainly from stem cell ageing and "inflammaging". Mesenchymal stem cells (MSCs) exhibit very high immune-regulating capacity and are promising candidates for immune-related disease treatment. However, the effect of MSC application is not satisfactory for some patients, especially in elderly individuals. With ageing, MSCs undergo many changes, including altered cell population reduction and differentiation ability, reduced migratory and homing capacity and, most important, defective immunosuppression. It is necessary to explore the relationship between the "inflammaging" and aged MSCs to prevent age-related diseases and increase the therapeutic effects of MSCs. In this review, we discuss changes in naturally ageing MSCs mainly from an inflammation perspective and propose some ideas for rejuvenating aged MSCs in future treatments.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Células Madre Mesenquimatosas / Inflamación Límite: Aged / Humans Idioma: En Revista: Biol Direct Año: 2023 Tipo del documento: Article País de afiliación: Italia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Células Madre Mesenquimatosas / Inflamación Límite: Aged / Humans Idioma: En Revista: Biol Direct Año: 2023 Tipo del documento: Article País de afiliación: Italia