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Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma.
Graziano, Vincenzo; Dannhorn, Andreas; Hulme, Heather; Williamson, Kate; Buckley, Hannah; Karim, Saadia A; Wilson, Matthew; Lee, Sheng Y; Kaistha, Brajesh P; Islam, Sabita; Thaventhiran, James E D; Richards, Frances M; Goodwin, Richard; Brais, Rebecca; Morton, Jennifer P; Dovedi, Simon J; Schuller, Alwin G; Eyles, Jim; Jodrell, Duncan I.
Afiliación
  • Graziano V; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK vincenzo.graziano@astrazeneca.com Duncan.Jodrell@cruk.cam.ac.uk.
  • Dannhorn A; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, UK.
  • Hulme H; Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences (CPSS), AstraZeneca R&D, Cambridge, UK.
  • Williamson K; Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences (CPSS), AstraZeneca R&D, Cambridge, UK.
  • Buckley H; Medical Research Council Toxicology Unit, University of Cambridge, Cambridge, UK.
  • Karim SA; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
  • Wilson M; Cancer Research UK Beatson Institute, Glasgow, UK.
  • Lee SY; Oncology R&D, Research and Early Development, AstraZeneca R&D, Cambridge, UK.
  • Kaistha BP; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
  • Islam S; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
  • Thaventhiran JED; Department of Oncology, University of Cambridge, Cambridge, UK.
  • Richards FM; Medical Research Council Toxicology Unit, University of Cambridge, Cambridge, UK.
  • Goodwin R; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
  • Brais R; Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences (CPSS), AstraZeneca R&D, Cambridge, UK.
  • Morton JP; Department of Pathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
  • Dovedi SJ; Cancer Research UK Beatson Institute, Glasgow, UK.
  • Schuller AG; School of Cancer Sciences, University of Glasgow, Glasgow, UK.
  • Eyles J; Oncology R&D, Research and Early Development, AstraZeneca R&D, Cambridge, UK.
  • Jodrell DI; Oncology, AstraZeneca R&D Boston, Waltham, Massachusetts, USA.
J Immunother Cancer ; 11(8)2023 08.
Article en En | MEDLINE | ID: mdl-37553182
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Carcinoma Ductal Pancreático Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Immunother Cancer Año: 2023 Tipo del documento: Article
Texto completo
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XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Carcinoma Ductal Pancreático Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Immunother Cancer Año: 2023 Tipo del documento: Article