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Modified red light 5-aminolevulinic acid photodynamic therapy versus low-dose isotretinoin therapy for moderate to severe acne vulgaris: A prospective, randomized, multicenter study.
Zhang, Linglin; Yang, Yutong; Wang, Bo; Zhao, Yan; Wang, Peiru; Liu, Jia; Yang, Jiayi; Wu, Yun; Lv, Ting; Wei, Ziyu; Liu, Xiaojing; Wang, Ruiping; Wong, Harrison; Ju, Qiang; Shi, Lei; Wang, Xiuli.
Afiliación
  • Zhang L; Department of Phototherapy, Shanghai Skin Disease Hospital, Institute of Photomedicine, Tongji University School of Medicine, Shanghai, China.
  • Yang Y; Department of Phototherapy, Shanghai Skin Disease Hospital, Institute of Photomedicine, Tongji University School of Medicine, Shanghai, China.
  • Wang B; Department of Dermatology, University of Michigan, Ann Arbor, Michigan; Department of Dermatology, Avera Medical Group Dermatology Aberdeen, Aberdeen, South Dakota.
  • Zhao Y; Department of Phototherapy, Shanghai Skin Disease Hospital, Institute of Photomedicine, Tongji University School of Medicine, Shanghai, China.
  • Wang P; Department of Phototherapy, Shanghai Skin Disease Hospital, Institute of Photomedicine, Tongji University School of Medicine, Shanghai, China.
  • Liu J; Department of Phototherapy, Shanghai Skin Disease Hospital, Institute of Photomedicine, Tongji University School of Medicine, Shanghai, China.
  • Yang J; Department of Phototherapy, Shanghai Skin Disease Hospital, Institute of Photomedicine, Tongji University School of Medicine, Shanghai, China.
  • Wu Y; Department of Phototherapy, Shanghai Skin Disease Hospital, Institute of Photomedicine, Tongji University School of Medicine, Shanghai, China.
  • Lv T; Department of Dermatology, Huadong Hospital, Fudan University, Shanghai, China.
  • Wei Z; Department of Dermatology, Renji Hospital, School of Medicine, Shanghai, Jiaotong University, Shanghai, China.
  • Liu X; Department of Phototherapy, Shanghai Skin Disease Hospital, Institute of Photomedicine, Tongji University School of Medicine, Shanghai, China.
  • Wang R; Clinical Research Center, Shanghai Skin Disease Hospital, Tongji University, Shanghai, China.
  • Wong H; Department of Dermatology, University of Michigan, Ann Arbor, Michigan.
  • Ju Q; Department of Dermatology, Renji Hospital, School of Medicine, Shanghai, Jiaotong University, Shanghai, China. Electronic address: qiangju@aliyun.com.
  • Shi L; Department of Dermatology, Huadong Hospital, Fudan University, Shanghai, China. Electronic address: leishinsh@163.com.
  • Wang X; Department of Phototherapy, Shanghai Skin Disease Hospital, Institute of Photomedicine, Tongji University School of Medicine, Shanghai, China. Electronic address: wangxiuli_1400023@tongji.edu.cn.
J Am Acad Dermatol ; 89(6): 1141-1148, 2023 12.
Article en En | MEDLINE | ID: mdl-37558093
ABSTRACT

BACKGROUND:

Modified 5-aminolevulinic acid photodynamic therapy (M-PDT) and isotretinoin (ISO) are effective treatments for moderate to severe acne vulgaris.

OBJECTIVE:

To evaluate the efficacy and adverse effects of M-PDT and ISO for moderate to severe acne vulgaris.

METHODS:

A multicenter, randomized clinical trial was conducted with participants randomly assigned to the M-PDT group (up to 5 weekly sessions following manual comedone extraction) or the ISO group (oral ISO, 0.5 mg/kg/d for 6 months) and followed up to 6-months after therapy.

RESULTS:

A total of 152 patients were allocated. The overall effective rates in the M-PDT group were significantly higher than the ISO group at 1 month (67.74% vs 10.26%), whereas the opposite was the case 1 month after treatment (75.81% vs 97.44%). Time to achieve 50% lesion improvement in the M-PDT group was significantly less than the ISO group (1 vs 8 weeks). Overall, 70.67% of the ISO group patients experienced systemic side effects such as hepatotoxicity, whereas side effects were skin-limited in the M-PDT group.

LIMITATIONS:

Limitations of this study included relatively low numbers of participants and high withdrawal rate.

CONCLUSION:

M-PDT offers a more rapid onset of improvement, comparable overall efficacy, good tolerability, and comparable durability of response compared with ISO.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Acné Vulgar Tipo de estudio: Clinical_trials / Guideline Límite: Humans Idioma: En Revista: J Am Acad Dermatol Año: 2023 Tipo del documento: Article País de afiliación: China
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Acné Vulgar Tipo de estudio: Clinical_trials / Guideline Límite: Humans Idioma: En Revista: J Am Acad Dermatol Año: 2023 Tipo del documento: Article País de afiliación: China