Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity.
Chem Commun (Camb)
; 59(71): 10660-10663, 2023 Aug 31.
Article
en En
| MEDLINE
| ID: mdl-37581279
ABSTRACT
Piperic acid derivatives were found to affect the islet amyloid polypeptide (IAPP) aggregation process. Structure-activity relationship studies revealed that PAD-13 was an efficient molecular modulator to accelerate IAPP fibril formation by promoting primary and secondary nucleation and reducing its antimicrobial activity.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Polipéptido Amiloide de los Islotes Pancreáticos
/
Antiinfecciosos
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Taiwán