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Hyperpolarized [2-13C]pyruvate MR molecular imaging with whole brain coverage.
Chung, Brian T; Kim, Yaewon; Gordon, Jeremy W; Chen, Hsin-Yu; Autry, Adam W; Lee, Philip M; Hu, Jasmine Y; Tan, Chou T; Suszczynski, Chris; Chang, Susan M; Villanueva-Meyer, Javier E; Bok, Robert A; Larson, Peder E Z; Xu, Duan; Li, Yan; Vigneron, Daniel B.
Afiliación
  • Chung BT; Department of Radiology and Biomedical Imaging, University of California, 1700 Fourth Street, Byers Hall Suite 102, San Francisco, CA 94158, USA; UCSF - UC Berkeley Graduate Program in Bioengineering, University of California, USA.
  • Kim Y; Department of Radiology and Biomedical Imaging, University of California, 1700 Fourth Street, Byers Hall Suite 102, San Francisco, CA 94158, USA. Electronic address: yaewon.kim@ucsf.edu.
  • Gordon JW; Department of Radiology and Biomedical Imaging, University of California, 1700 Fourth Street, Byers Hall Suite 102, San Francisco, CA 94158, USA.
  • Chen HY; Department of Radiology and Biomedical Imaging, University of California, 1700 Fourth Street, Byers Hall Suite 102, San Francisco, CA 94158, USA.
  • Autry AW; Department of Radiology and Biomedical Imaging, University of California, 1700 Fourth Street, Byers Hall Suite 102, San Francisco, CA 94158, USA.
  • Lee PM; Department of Radiology and Biomedical Imaging, University of California, 1700 Fourth Street, Byers Hall Suite 102, San Francisco, CA 94158, USA; UCSF - UC Berkeley Graduate Program in Bioengineering, University of California, USA.
  • Hu JY; Department of Radiology and Biomedical Imaging, University of California, 1700 Fourth Street, Byers Hall Suite 102, San Francisco, CA 94158, USA; UCSF - UC Berkeley Graduate Program in Bioengineering, University of California, USA.
  • Tan CT; ISOTEC Stable Isotope Division, MilliporeSigma, Merck KGaA, Miamisburg, OH 45342, USA.
  • Suszczynski C; ISOTEC Stable Isotope Division, MilliporeSigma, Merck KGaA, Miamisburg, OH 45342, USA.
  • Chang SM; Department of Neurological Surgery, University of California, San Francisco, CA 94158, USA.
  • Villanueva-Meyer JE; Department of Radiology and Biomedical Imaging, University of California, 1700 Fourth Street, Byers Hall Suite 102, San Francisco, CA 94158, USA.
  • Bok RA; Department of Radiology and Biomedical Imaging, University of California, 1700 Fourth Street, Byers Hall Suite 102, San Francisco, CA 94158, USA.
  • Larson PEZ; Department of Radiology and Biomedical Imaging, University of California, 1700 Fourth Street, Byers Hall Suite 102, San Francisco, CA 94158, USA; UCSF - UC Berkeley Graduate Program in Bioengineering, University of California, USA.
  • Xu D; Department of Radiology and Biomedical Imaging, University of California, 1700 Fourth Street, Byers Hall Suite 102, San Francisco, CA 94158, USA; UCSF - UC Berkeley Graduate Program in Bioengineering, University of California, USA.
  • Li Y; Department of Radiology and Biomedical Imaging, University of California, 1700 Fourth Street, Byers Hall Suite 102, San Francisco, CA 94158, USA.
  • Vigneron DB; Department of Radiology and Biomedical Imaging, University of California, 1700 Fourth Street, Byers Hall Suite 102, San Francisco, CA 94158, USA; UCSF - UC Berkeley Graduate Program in Bioengineering, University of California, USA; Department of Neurological Surgery, University of California, San Fr
Neuroimage ; 280: 120350, 2023 10 15.
Article en En | MEDLINE | ID: mdl-37634883
ABSTRACT
Hyperpolarized (HP) 13C Magnetic Resonance Imaging (MRI) was applied for the first time to image and quantify the uptake and metabolism of [2-13C]pyruvate in the human brain to provide new metabolic information on cerebral energy metabolism. HP [2-13C]pyruvate was injected intravenously and imaged in 5 healthy human volunteer exams with whole brain coverage in a 1-minute acquisition using a specialized spectral-spatial multi-slice echoplanar imaging (EPI) pulse sequence to acquire 13C-labeled volumetric and dynamic images of [2-13C]pyruvate and downstream metabolites [5-13C]glutamate and [2-13C]lactate. Metabolic ratios and apparent conversion rates of pyruvate-to-lactate (kPL) and pyruvate-to-glutamate (kPG) were quantified to investigate simultaneously glycolytic and oxidative metabolism in a single injection.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Ácido Pirúvico Límite: Humans Idioma: En Revista: Neuroimage Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Ácido Pirúvico Límite: Humans Idioma: En Revista: Neuroimage Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos