Biological embedding of early trauma: the role of higher prefrontal synaptic strength.
Eur J Psychotraumatol
; 14(2): 2246338, 2023.
Article
en En
| MEDLINE
| ID: mdl-37642398
Abnormalities in the strength of synaptic connections have been implicated in trauma and trauma-related disorders but not directly examined.We used magnetic resonance spectroscopy to investigate the association between early trauma and an in vivo measure of synaptic strength.For people with posttraumatic stress disorder, as early trauma severity increased, synaptic strength increased, highlighting the potential for treatments thought to change synaptic connections in trauma-related disorders.
Palabras clave
PTSD; Plasticidad sináptica; Synaptic plasticity; TEPT; childhood maltreatment; childhood trauma; espectroscopia de resonancia magnética; glutamate; glutamato; magnetic resonance spectroscopy; maltrato infantil; trauma infantil; ç£å
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Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Ketamina
Tipo de estudio:
Prognostic_studies
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Eur J Psychotraumatol
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos