Your browser doesn't support javascript.
loading
Investigating cerebral perfusion with high resolution hyperpolarized [1-13 C]pyruvate MRI.
Hu, Jasmine Y; Vaziri, Sana; Bøgh, Nikolaj; Kim, Yaewon; Autry, Adam W; Bok, Robert A; Li, Yan; Laustsen, Christoffer; Xu, Duan; Larson, Peder E Z; Chang, Susan; Vigneron, Daniel B; Gordon, Jeremy W.
Afiliación
  • Hu JY; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
  • Vaziri S; UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, San Francisco and University of California, Berkeley, California, USA.
  • Bøgh N; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
  • Kim Y; MR Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
  • Autry AW; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
  • Bok RA; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
  • Li Y; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
  • Laustsen C; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
  • Xu D; UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, San Francisco and University of California, Berkeley, California, USA.
  • Larson PEZ; MR Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
  • Chang S; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
  • Vigneron DB; UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, San Francisco and University of California, Berkeley, California, USA.
  • Gordon JW; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
Magn Reson Med ; 90(6): 2233-2241, 2023 12.
Article en En | MEDLINE | ID: mdl-37665726
ABSTRACT

PURPOSE:

To investigate high-resolution hyperpolarized (HP) 13 C pyruvate MRI for measuring cerebral perfusion in the human brain.

METHODS:

HP [1-13 C]pyruvate MRI was acquired in five healthy volunteers with a multi-resolution EPI sequence with 7.5 × 7.5 mm2 resolution for pyruvate. Perfusion parameters were calculated from pyruvate MRI using block-circulant singular value decomposition and compared to relative cerebral blood flow calculated from arterial spin labeling (ASL). To examine regional perfusion patterns, correlations between pyruvate and ASL perfusion were performed for whole brain, gray matter, and white matter voxels.

RESULTS:

High resolution 7.5 × 7.5 mm2 pyruvate images were used to obtain relative cerebral blood flow (rCBF) values that were significantly positively correlated with ASL rCBF values (r = 0.48, 0.20, 0.28 for whole brain, gray matter, and white matter voxels respectively). Whole brain voxels exhibited the highest correlation between pyruvate and ASL perfusion, and there were distinct regional patterns of relatively high ASL and low pyruvate normalized rCBF found across subjects.

CONCLUSION:

Acquiring HP 13 C pyruvate metabolic images at higher resolution allows for finer spatial delineation of brain structures and can be used to obtain cerebral perfusion parameters. Pyruvate perfusion parameters were positively correlated to proton ASL perfusion values, indicating a relationship between the two perfusion measures. This HP 13 C study demonstrated that hyperpolarized pyruvate MRI can assess cerebral metabolism and perfusion within the same study.
Asunto(s)
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Ácido Pirúvico Límite: Humans Idioma: En Revista: Magn Reson Med Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Ácido Pirúvico Límite: Humans Idioma: En Revista: Magn Reson Med Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos