Nimodipine Reduces Microvasospasms After Experimental Subarachnoid Hemorrhage.
Stroke
; 54(10): 2666-2670, 2023 10.
Article
en En
| MEDLINE
| ID: mdl-37675614
ABSTRACT
BACKGROUND:
The only established pharmacological treatment option improving outcomes for patients suffering from subarachnoid hemorrhage (SAH) is the L-type-calcium channel inhibitor nimodipine. However, the exact mechanisms of action of nimodipine conferring neuroprotection after SAH have yet to be determined. More recently, spasms of the cerebral microcirculation were suggested to play an important role in reduced cerebral perfusion after SAH and, ultimately, outcome. It is unclear whether nimodipine may influence microvasospasms and, thus, microcirculatory dysfunction. The aim of the current study was, therefore, to assess the effect of nimodipine on microvasospasms after experimental SAH.METHODS:
Male C57Bl/6 N mice (n=3-5/group) were subjected to SAH using the middle cerebral artery perforation model. Six hours after SAH induction, a cranial window was prepared, and the diameter of cortical microvessels was assessed in vivo by 2-photon-microscopy before, during, and after nimodipine application.RESULTS:
Nimodipine significantly reduced the number of posthemorrhagic microvasospasms. The diameters of nonspastic vessels were not affected.CONCLUSIONS:
Our results show that nimodipine reduces the formation of microvasospasms, thus, shedding new light on the mode of action of a drug routinely used for the treatment of SAH for >3 decades. Furthermore, L-type Ca2+ channels may be involved in the pathophysiology of microvasospasm formation.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Hemorragia Subaracnoidea
/
Nimodipina
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Stroke
Año:
2023
Tipo del documento:
Article