Histone mutations in cancer.
Biochem Soc Trans
; 51(5): 1749-1763, 2023 10 31.
Article
en En
| MEDLINE
| ID: mdl-37721138
ABSTRACT
Genes encoding histone proteins are recurrently mutated in tumor samples, and these mutations may impact nucleosome stability, histone post-translational modification, or chromatin dynamics. The prevalence of histone mutations across diverse cancer types suggest that normal chromatin structure is a barrier to tumorigenesis. Oncohistone mutations disrupt chromatin structure and gene regulatory mechanisms, resulting in aberrant gene expression and the development of cancer phenotypes. Examples of oncohistones include the histone H3 K27M mutation found in pediatric brain cancers that blocks post-translational modification of the H3 N-terminal tail and the histone H2B E76K mutation found in some solid tumors that disrupts nucleosome stability. Oncohistones may comprise a limited fraction of the total histone pool yet cause global effects on chromatin structure and drive cancer phenotypes. Here, we survey histone mutations in cancer and review their function and role in tumorigenesis.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Histonas
/
Neoplasias
Tipo de estudio:
Risk_factors_studies
Límite:
Child
/
Humans
Idioma:
En
Revista:
Biochem Soc Trans
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos