New Antimicrobials for Gram-Positive Sustained Infections: A Comprehensive Guide for Clinicians.
Pharmaceuticals (Basel)
; 16(9)2023 Sep 15.
Article
en En
| MEDLINE
| ID: mdl-37765112
ABSTRACT
Antibiotic resistance is a public health problem with increasingly alarming data being reported. Gram-positive bacteria are among the protagonists of severe nosocomial and community infections. The objective of this review is to conduct an extensive examination of emerging treatments for Gram-positive infections including ceftobiprole, ceftaroline, dalbavancin, oritavancin, omadacycline, tedizolid, and delafloxacin. From a methodological standpoint, a comprehensive analysis on clinical trials, molecular structure, mechanism of action, microbiological targeting, clinical use, pharmacokinetic/pharmacodynamic features, and potential for therapeutic drug monitoring will be addressed. Each antibiotic paragraph is divided into specialized microbiological, clinical, and pharmacological sections, including detailed and appropriate tables. A better understanding of the latest promising advances in the field of therapeutic options could lead to the development of a better approach in managing antimicrobial therapy for multidrug-resistant Gram-positive pathogens, which increasingly needs to be better stratified and targeted.
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Base de datos:
MEDLINE
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En
Revista:
Pharmaceuticals (Basel)
Año:
2023
Tipo del documento:
Article
País de afiliación:
Italia