Discovery of a novel NAMPT inhibitor that selectively targets NAPRT-deficient EMT-subtype cancer cells and alleviates chemotherapy-induced peripheral neuropathy.

Kim, Minjee; Kim, Hyeyoung; Kang, Bu-Gyeong; Lee, Jooyoung; Kim, Taegun; Lee, Hwanho; Jung, Jane; Oh, Myung Joon; Seo, Seungyoon; Ryu, Myung-Jeom; Sung, Yeojin; Lee, Yunji; Yeom, Jeonghun; Han, Gyoonhee; Cha, Sun-Shin; Jung, Hosung; Kim, Hyun Seok

Kim, Minjee; Kim, Hyeyoung; Kang, Bu-Gyeong; Lee, Jooyoung; Kim, Taegun; Lee, Hwanho; Jung, Jane; Oh, Myung Joon; Seo, Seungyoon; Ryu, Myung-Jeom; Sung, Yeojin; Lee, Yunji; Yeom, Jeonghun; Han, Gyoonhee; Cha, Sun-Shin; Jung, Hosung; Kim, Hyun Seok.

Afiliación

Kim M; Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
Kim H; Department of Biomedical Sciences, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
Kang BG; Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
Lee J; Department of Anatomy, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
Kim T; Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760, Republic of Korea.
Lee H; Department of Biomedical Sciences, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
Jung J; Checkmate Therapeutics Inc., Seoul, 07207, Republic of Korea.
Oh MJ; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Republic of Korea.
Seo S; Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
Ryu MJ; Department of Biomedical Sciences, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
Sung Y; Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
Lee Y; Department of Anatomy, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
Yeom J; Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
Han G; Department of Biomedical Sciences, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
Cha SS; Prometabio Research Institute, Prometabio Co., Ltd. Hanam-si, Gyeonggi-do 12939, Republic of Korea.
Jung H; Department of Biomedical Sciences, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
Kim HS; Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.

Theranostics ; 13(14): 5075-5098, 2023.

Article en En | MEDLINE | ID: mdl-37771778

Palabras clave

Chemotherapy-induced peripheral neuropathy (CIPN); Epithelial-to-mesenchymal transition (EMT); NAMPT inhibitor; Synthetic lethality; Wallerian degeneration

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