The Effect of Menopause and Menopausal Hormone Therapy on the Risk of Peripheral Artery Disease.
Curr Vasc Pharmacol
; 21(5): 293-296, 2023.
Article
en En
| MEDLINE
| ID: mdl-37779405
ABSTRACT
Peripheral artery disease (PAD), defined as lower extremity arterial disease, constitutes an underestimated aspect of the menopause-associated risk of atherosclerotic cardiovascular disease (ASCVD). Accumulation of ASCVD risk factors, such as atherogenic dyslipidaemia, diabetes, and arterial hypertension, after the transition to menopause may contribute to atherosclerotic plaque formation in peripheral arteries. However, inconsistency exists among studies as to whether transition to menopause increases the risk of PAD, although early menopause (<45 years) or premature ovarian insufficiency may accelerate peripheral atherosclerotic plaque formation. Menopausal hormone therapy may decrease the risk of PAD if administered early (i.e., within the first 5-6 years after last menstruation), whereas it has no effect in women with established ASCVD.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Menopausia Prematura
/
Insuficiencia Ovárica Primaria
/
Aterosclerosis
/
Enfermedad Arterial Periférica
/
Placa Aterosclerótica
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
Idioma:
En
Revista:
Curr Vasc Pharmacol
Asunto de la revista:
ANGIOLOGIA
/
FARMACOLOGIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Grecia