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Fostemsavir resistance-associated polymorphisms in HIV-1 subtype C in a large cohort of treatment-naïve and treatment-experienced individuals in Botswana.
Zuze, Boitumelo J L; Radibe, Botshelo T; Choga, Wonderful T; Bareng, Ontlametse T; Moraka, Natasha O; Maruapula, Dorcas; Seru, Kedumetse; Mokgethi, Patrick; Mokaleng, Baitshepi; Ndlovu, Nokuthula; Kelentse, Nametso; Pretorius-Holme, Molly; Shapiro, Roger; Lockman, Shahin; Makhema, Joseph; Novitsky, Vlad; Seatla, Kaelo K; Moyo, Sikhulile; Gaseitsiwe, Simani.
Afiliación
  • Zuze BJL; Botswana Harvard AIDS Institute Partnership , Gaborone, Botswana.
  • Radibe BT; Botswana Harvard AIDS Institute Partnership , Gaborone, Botswana.
  • Choga WT; Botswana Harvard AIDS Institute Partnership , Gaborone, Botswana.
  • Bareng OT; Department of Medical Sciences, Faculty of Allied Health Professions, University of Botswana , Gaborone, Botswana.
  • Moraka NO; Botswana Harvard AIDS Institute Partnership , Gaborone, Botswana.
  • Maruapula D; Department of Medical Sciences, Faculty of Allied Health Professions, University of Botswana , Gaborone, Botswana.
  • Seru K; Botswana Harvard AIDS Institute Partnership , Gaborone, Botswana.
  • Mokgethi P; Department of Medical Sciences, Faculty of Allied Health Professions, University of Botswana , Gaborone, Botswana.
  • Mokaleng B; Botswana Harvard AIDS Institute Partnership , Gaborone, Botswana.
  • Ndlovu N; Department of Biological Sciences, Faculty of Science, University of Botswana , Gaborone, Botswana.
  • Kelentse N; Botswana Harvard AIDS Institute Partnership , Gaborone, Botswana.
  • Pretorius-Holme M; Botswana Harvard AIDS Institute Partnership , Gaborone, Botswana.
  • Shapiro R; Department of Biological Sciences, Faculty of Science, University of Botswana , Gaborone, Botswana.
  • Lockman S; Botswana Harvard AIDS Institute Partnership , Gaborone, Botswana.
  • Makhema J; Department of Medical Sciences, Faculty of Allied Health Professions, University of Botswana , Gaborone, Botswana.
  • Novitsky V; Botswana Harvard AIDS Institute Partnership , Gaborone, Botswana.
  • Seatla KK; Botswana Harvard AIDS Institute Partnership , Gaborone, Botswana.
  • Moyo S; Department of Medical Sciences, Faculty of Allied Health Professions, University of Botswana , Gaborone, Botswana.
  • Gaseitsiwe S; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health , Boston, Massachusetts, USA.
Microbiol Spectr ; 11(6): e0125123, 2023 Dec 12.
Article en En | MEDLINE | ID: mdl-37823653
ABSTRACT
IMPORTANCE Fostemsavir (FTR) is a newly licensed antiretroviral drug that has been shown to have activity against HIV-1. The mechanism of action of FTR is different from all currently available antiretrovirals (ARVs), and as such, it offers hope for HIV-1 suppression in those people with HIV (PWH) who harbor HIV-1 variants with drug resistance mutations to currently used ARVs. Using 6,030 HIV-1 sequences covering the HIV-1 envelope from PWH in Botswana who are antiretroviral therapy (ART) naïve as well as those who are failing ART, we explored the sequences for FTR resistance-associated polymorphisms. We found the prevalence of FTR polymorphisms to be similar in both ART-naïve and ART-experienced individuals with VF in this setting, with no prior FTR exposure. Further studies on the phenotypic impact of these polymorphisms are warranted to guide how to monitor for FTR resistance.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH-1 / Fármacos Anti-VIH Tipo de estudio: Qualitative_research / Risk_factors_studies Límite: Humans País/Región como asunto: Africa Idioma: En Revista: Microbiol Spectr Año: 2023 Tipo del documento: Article País de afiliación: Botswana
Texto completo
Imprimir
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PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH-1 / Fármacos Anti-VIH Tipo de estudio: Qualitative_research / Risk_factors_studies Límite: Humans País/Región como asunto: Africa Idioma: En Revista: Microbiol Spectr Año: 2023 Tipo del documento: Article País de afiliación: Botswana