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Nodular type but not vitamin D levels increases the risk of second primary cancers in melanoma patients: An observational study of 663 patients.
Massa, A; Isasi-Fuster, A; Requena, C; Manrique-Silva, E; Kumar, R; Nagore, E.
Afiliación
  • Massa A; Section of Dermatology, Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy.
  • Isasi-Fuster A; School of Medicine, Universidad Católica de Valencia San Vicente Mártir, València, Spain.
  • Requena C; Department of Dermatology, Fundación Instituto Valenciano de Oncología, València, Spain.
  • Manrique-Silva E; Department of Dermatology, Fundación Instituto Valenciano de Oncología, València, Spain.
  • Kumar R; Institute of Medical Biometry, University of Heidelberg, Heidelberg, Germany; Institute of Experimental Medicine, Czech Academy of Sciences, Prague, Czech Republic.
  • Nagore E; School of Medicine, Universidad Católica de Valencia San Vicente Mártir, València, Spain; Department of Dermatology, Fundación Instituto Valenciano de Oncología, València, Spain. Electronic address: eduardo.nagore@ucv.es.
Actas Dermosifiliogr ; 115(2): 143-149, 2024 Feb.
Article en En, Es | MEDLINE | ID: mdl-37832865
BACKGROUND: Vitamin D deficiency associates with the risk of developing many diseases, including cancer. At the molecular level, vitamin D appears to have an antineoplastic effect. However, the role of vitamin D deficiency in cancer pathogenesis remains unelucidated and numerous studies have resulted in discordant results. This study aimed to determine whether vitamin D deficiency during melanoma diagnosis increases the risk of developing non-cutaneous second primary cancers (SPC). MATERIALS AND METHODS: A retrospective study on 663 patients diagnosed with melanoma between 1 January 2011 and 31 October 2022. The effect of each variable on the development of a subsequent non-cutaneous cancer was performed using Kaplan-Meier curves and differences were assessed by log-rank tests. Cox proportional hazard univariate and multivariate models were used to quantify the effect of each variable in the time to develop a non-cutaneous neoplasia. RESULTS: Out of 663 patients, 34 developed a non-cutaneous SPC. There was no statistically significant association between vitamin D levels and non-cutaneous SPC development (log-rank, p=0.761). Age>60 years, stage III/IV, and nodular melanoma subtype were significantly associated with the development of a SPC. After multivariate analysis, only age>60 years (HR 3.4; HR CI 95%: 1.5-7.6) and nodular melanoma subtype (HR 2.2; HR CI 95%: 1.0-4.8) were included in the final model. CONCLUSIONS: Our results suggest that vitamin D deficiency is not associated with an increased risk of developing non-cutaneous SPC in melanoma patients. However, age over 60 years and nodular melanoma subtype increase the risk for non-cutaneous SPC development.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Deficiencia de Vitamina D / Neoplasias Primarias Secundarias / Melanoma Límite: Humans / Middle aged Idioma: En / Es Revista: Actas Dermosifiliogr Año: 2024 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Deficiencia de Vitamina D / Neoplasias Primarias Secundarias / Melanoma Límite: Humans / Middle aged Idioma: En / Es Revista: Actas Dermosifiliogr Año: 2024 Tipo del documento: Article País de afiliación: Italia