Multifunctional Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9-Based Nanobomb against Carbapenem-Resistant <i>Acinetobacter baumannii</i> Infection through Cascade Reaction and Amplification Synergistic Effect.

Li, Xisheng; Gui, Shumin; Gui, Rong; Li, Jian; Huang, Rong; Hu, Min; Luo, Xiu-Ju; Nie, Xinmin

Multifunctional Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9-Based Nanobomb against Carbapenem-Resistant Acinetobacter baumannii Infection through Cascade Reaction and Amplification Synergistic Effect.

Li, Xisheng; Gui, Shumin; Gui, Rong; Li, Jian; Huang, Rong; Hu, Min; Luo, Xiu-Ju; Nie, Xinmin.

Afiliación

Li X; Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, P. R. China.
Gui S; Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, P. R. China.
Gui R; Department of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, P. R. China.
Li J; Department of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, P. R. China.
Huang R; Department of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, P. R. China.
Hu M; Department of Laboratory Medicine, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, P. R. China.
Luo XJ; Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, P. R. China.
Nie X; Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, P. R. China.

ACS Nano ; 17(24): 24632-24653, 2023 Dec 26.

Article en En | MEDLINE | ID: mdl-37874946

Asunto(s)

Infecciones por Acinetobacter; Acinetobacter baumannii; Animales; Ratones; Acinetobacter baumannii/genética; Sistemas CRISPR-Cas; ARN Guía de Sistemas CRISPR-Cas; Infecciones por Acinetobacter/tratamiento farmacológico; Infecciones por Acinetobacter/genética; Infecciones por Acinetobacter/microbiología; Farmacorresistencia Bacteriana; Antibacterianos/farmacología; Antibacterianos/uso terapéutico; Carbapenémicos/farmacología; Carbapenémicos/uso terapéutico; Imipenem/farmacología; Imipenem/uso terapéutico; Pruebas de Sensibilidad Microbiana

Palabras clave

CRISPR/Cas9-sgRNA; amplification; bactericidal; carbapenem-resistant Acinetobacter baumannii; cascade reaction; nanosystem

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Infecciones por Acinetobacter / Acinetobacter baumannii Límite: Animals Idioma: En Revista: ACS Nano Año: 2023 Tipo del documento: Article

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