Language MEG predicts postoperative verbal memory change in left mesial temporal lobe epilepsy.
Clin Neurophysiol
; 156: 69-75, 2023 12.
Article
en En
| MEDLINE
| ID: mdl-37890232
ABSTRACT
OBJECTIVE:
To clarify whether preoperative language magnetoencephalography (MEG) predicts postoperative verbal memory (VM) changes in left mesial temporal lobe epilepsy (LMTLE).METHODS:
We reviewed 18 right-handed patients with LMTLE who underwent anterior temporal lobectomy or selective amygdala hippocampectomy, 12 with (HS+) and 6 without hippocampal sclerosis (HS-). Patients underwent neuropsychological assessment before and after surgery. MEG was measured with an auditory verbal learning task in patients preoperatively and in 15 right-handed controls. Dynamic statistical parametric mapping (dSPM) was used for source imaging of task-related activity. Language laterality index (LI) was calculated by z-score of dSPM in language-related regions. LI in the region of HS+ and HS- was compared to controls. The correlation between LI and postoperative VM change was assessed in HS+ and HS-.RESULTS:
Preoperative LI in supramarginal gyrus showed greater right-shifted lateralization in both HS+ and HS- than in controls. Right-shifted LI in supramarginal gyrus was correlated with postoperative VM increase in HS+ (p = 0.019), but not in HS-.CONCLUSIONS:
Right-shifted language lateralization in dSPM of MEG signals may predict favorable VM outcome in HS+ of LMTLE.SIGNIFICANCE:
Findings warrant further investigation of the relation between regional language laterality index and postoperative verbal memory changes.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Epilepsia
/
Epilepsia del Lóbulo Temporal
Límite:
Humans
Idioma:
En
Revista:
Clin Neurophysiol
Asunto de la revista:
NEUROLOGIA
/
PSICOFISIOLOGIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Japón