Prediction of cancer recurrence based on compact graphs of whole slide images.
Comput Biol Med
; 167: 107663, 2023 12.
Article
en En
| MEDLINE
| ID: mdl-37931526
ABSTRACT
Cancer recurrence is one of the primary causes of patient mortality following treatment, indicating increased aggressiveness of cancer cells and difficulties in achieving a cure. A critical step to improve patients' survival is accurately predicting recurrence status and giving appropriate treatment. Whole Slide Images (WSIs) are a common type of image data in the field of digital pathology, containing high-resolution tissue information. Furthermore, WSIs of primary tumors contain microenvironmental information directly associated with the growth of tumor cells. To effectively utilize this microenvironmental information. Firstly, we represented microenvironmental features of histopathological images as compact graphs. Secondly, this work aims to develop an enhanced lightweight graph neural network called the Adaptive Graph Clustering Network (AGCNet) for predicting cancer recurrence. Experiments are conducted on three cancer datasets from The Cancer Genome Atlas (TCGA), and AGCNet achieved an accuracy of 81.81% in BLCA, 69.66% in PAAD, and 81.96% in STAD. These results indicated that AGCNet is an effective model for predicting cancer recurrence and is expected to be applied in clinical applications.
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Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Redes Neurales de la Computación
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Comput Biol Med
Año:
2023
Tipo del documento:
Article
País de afiliación:
China