Digestion is a critical element for absorption of cinnarizine from supersaturated lipid-based type I formulations.

Paulus, Felix; Bauer-Brandl, Annette; Stappaerts, Jef; Holm, René

Paulus, Felix; Bauer-Brandl, Annette; Stappaerts, Jef; Holm, René.

Afiliación

Paulus F; Janssen Pharmaceutica NV, Turnhoutseweg 30, Beerse 2340, Belgium; Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark.
Bauer-Brandl A; Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark.
Stappaerts J; Janssen Pharmaceutica NV, Turnhoutseweg 30, Beerse 2340, Belgium.
Holm R; Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, Odense 5230, Denmark. Electronic address: reho@sdu.dk.

Eur J Pharm Sci ; 192: 106634, 2024 Jan 01.

Article en En | MEDLINE | ID: mdl-37951315

Asunto(s)

Cinarizina; Ratas; Animales; Orlistat; Preparaciones Farmacéuticas; Triglicéridos; Solubilidad; Tensoactivos; Lipasa; Digestión; Administración Oral

Palabras clave

Drug solubility; Lipase inhibition; Lipid chain length; Lipid-based drug delivery systems; Pharmacokinetic study; Supersaturated lipid-based formulations

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Cinarizina Límite: Animals Idioma: En Revista: Eur J Pharm Sci Asunto de la revista: FARMACIA / FARMACOLOGIA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Dinamarca

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