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Small proteins modulate ion-channel-like ACD6 to regulate immunity in Arabidopsis thaliana.
Chen, Junbin; Li, Lei; Kim, Jong Hum; Neuhäuser, Benjamin; Wang, Mingyu; Thelen, Michael; Hilleary, Richard; Chi, Yuan; Wei, Luyang; Venkataramani, Kavita; Exposito-Alonso, Moises; Liu, Chang; Keck, Jakob; Barragan, A Cristina; Schwab, Rebecca; Lutz, Ulrich; Pei, Zhen-Ming; He, Sheng-Yang; Ludewig, Uwe; Weigel, Detlef; Zhu, Wangsheng.
Afiliación
  • Chen J; China Key Laboratory of Pest Monitoring and Green Management, MOA, State Key Laboratory of Maize Bio-breeding, and College of Plant Protection, China Agricultural University, Beijing 100193, China.
  • Li L; Department of Molecular Biology, Max Planck Institute for Biology Tübingen, 72076 Tübingen, Germany.
  • Kim JH; Department of Biology, Duke University, Durham, NC 27708, USA; Howard Hughes Medical Institute, Duke University, Durham, NC 27708, USA.
  • Neuhäuser B; Nutritional Crop Physiology, University of Hohenheim, 70599 Stuttgart, Germany.
  • Wang M; China Key Laboratory of Pest Monitoring and Green Management, MOA, State Key Laboratory of Maize Bio-breeding, and College of Plant Protection, China Agricultural University, Beijing 100193, China.
  • Thelen M; Department of Molecular Biology, Max Planck Institute for Biology Tübingen, 72076 Tübingen, Germany.
  • Hilleary R; Department of Biology, Duke University, Durham, NC 27708, USA.
  • Chi Y; Department of Biology, Duke University, Durham, NC 27708, USA.
  • Wei L; China Key Laboratory of Pest Monitoring and Green Management, MOA, State Key Laboratory of Maize Bio-breeding, and College of Plant Protection, China Agricultural University, Beijing 100193, China.
  • Venkataramani K; Department of Molecular Biology, Max Planck Institute for Biology Tübingen, 72076 Tübingen, Germany.
  • Exposito-Alonso M; Department of Molecular Biology, Max Planck Institute for Biology Tübingen, 72076 Tübingen, Germany.
  • Liu C; Center for Plant Molecular Biology (ZMBP), University of Tübingen, 72076 Tübingen, Germany; Institute of Biology, University of Hohenheim, 70599 Stuttgart, Germany.
  • Keck J; Department of Molecular Biology, Max Planck Institute for Biology Tübingen, 72076 Tübingen, Germany.
  • Barragan AC; Department of Molecular Biology, Max Planck Institute for Biology Tübingen, 72076 Tübingen, Germany.
  • Schwab R; Department of Molecular Biology, Max Planck Institute for Biology Tübingen, 72076 Tübingen, Germany.
  • Lutz U; Department of Molecular Biology, Max Planck Institute for Biology Tübingen, 72076 Tübingen, Germany.
  • Pei ZM; Department of Biology, Duke University, Durham, NC 27708, USA.
  • He SY; Department of Biology, Duke University, Durham, NC 27708, USA; Howard Hughes Medical Institute, Duke University, Durham, NC 27708, USA.
  • Ludewig U; Nutritional Crop Physiology, University of Hohenheim, 70599 Stuttgart, Germany.
  • Weigel D; Department of Molecular Biology, Max Planck Institute for Biology Tübingen, 72076 Tübingen, Germany; Institute for Bioinformatics and Medical Informatics, University of Tübingen, Tübingen, Germany. Electronic address: weigel@weigelworld.org.
  • Zhu W; China Key Laboratory of Pest Monitoring and Green Management, MOA, State Key Laboratory of Maize Bio-breeding, and College of Plant Protection, China Agricultural University, Beijing 100193, China; Department of Molecular Biology, Max Planck Institute for Biology Tübingen, 72076 Tübingen, Germany. E
Mol Cell ; 83(23): 4386-4397.e9, 2023 Dec 07.
Article en En | MEDLINE | ID: mdl-37995686
ABSTRACT
The multi-pass transmembrane protein ACCELERATED CELL DEATH 6 (ACD6) is an immune regulator in Arabidopsis thaliana with an unclear biochemical mode of action. We have identified two loci, MODULATOR OF HYPERACTIVE ACD6 1 (MHA1) and its paralog MHA1-LIKE (MHA1L), that code for ∼7 kDa proteins, which differentially interact with specific ACD6 variants. MHA1L enhances the accumulation of an ACD6 complex, thereby increasing the activity of the ACD6 standard allele for regulating plant growth and defenses. The intracellular ankyrin repeats of ACD6 are structurally similar to those found in mammalian ion channels. Several lines of evidence link increased ACD6 activity to enhanced calcium influx, with MHA1L as a direct regulator of ACD6, indicating that peptide-regulated ion channels are not restricted to animals.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Arabidopsis / Proteínas de Arabidopsis Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2023 Tipo del documento: Article País de afiliación: China
Texto completo
Imprimir
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Arabidopsis / Proteínas de Arabidopsis Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2023 Tipo del documento: Article País de afiliación: China