Timing of surfactant treatment in respiratory distress syndrome.
Semin Fetal Neonatal Med
; 28(6): 101495, 2023 12.
Article
en En
| MEDLINE
| ID: mdl-38012889
ABSTRACT
The introduction of exogenous surfactant in the 1980s has resulted in an improved survival of very preterm infants with respiratory distress syndrome (RDS). Randomized controlled trials conducted before 2000 have shown that the magnitude of this beneficial effect strongly depends on the timing of surfactant treatment, i.e. the earlier surfactant is administered after birth the better. However, the initial mode of respiratory support in infants with RDS has changed dramatically over the last decades, moving from invasive to non-invasive support. Furthermore, new, less invasive techniques to administer surfactant have been introduced to match this non-invasive approach. This review summarizes the evidence on how these practice changes impacted the effect of surfactant timing on mortality and morbidity in preterm infants with RDS.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Síndrome de Dificultad Respiratoria del Recién Nacido
/
Surfactantes Pulmonares
Límite:
Humans
/
Infant
/
Newborn
Idioma:
En
Revista:
Semin Fetal Neonatal Med
Asunto de la revista:
PEDIATRIA
/
PERINATOLOGIA
Año:
2023
Tipo del documento:
Article