Anti-virulence and bactericidal activities of Stattic against Shigella sonnei.
Appl Environ Microbiol
; 89(12): e0107423, 2023 12 21.
Article
en En
| MEDLINE
| ID: mdl-38032177
ABSTRACT
IMPORTANCE Shigella sonnei is a major human enteric pathogen that causes bacillary dysentery. The increasing spread of drug-resistant S. sonnei strains has caused an emergent need for the development of new antimicrobial agents against this pathogenic bacterium. In this study, we demonstrate that Stattic employs two antibacterial mechanisms against S. sonnei. It exerted both anti-virulence activity and bactericidal activity against S. sonnei, suggesting that it shows advantages over traditional antibiotics. Moreover, Stattic showed excellent synergistic effects with kanamycin, ampicillin, chloramphenicol, and gentamicin against S. sonnei. Our findings suggest that Stattic has promising potential for development as a new antibiotic or as an adjuvant to antibiotics for infections caused by S. sonnei.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Shigella
/
Disentería Bacilar
Límite:
Humans
Idioma:
En
Revista:
Appl Environ Microbiol
Año:
2023
Tipo del documento:
Article
País de afiliación:
China