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A case of bullous pemphigoid and renal disease after dipeptidyl peptidase 4 inhibitor administration.
Suenaga, Atsuhiko; Sawa, Naoki; Oba, Yuki; Ikuma, Daisuke; Sekine, Akinari; Yamanouchi, Masayuki; Hasegawa, Eiko; Mizuno, Hiroki; Suwabe, Tatsuya; Hayashi, Nobukazu; Kono, Kei; Kinowaki, Keiichi; Ohashi, Kenichi; Miyazono, Motoaki; Yamaguchi, Yutaka; Ubara, Yoshifumi.
Afiliación
  • Suenaga A; Department of Nephrology and Rheumatology, Toranomon Hospital Kajigaya, 1-3-1, Takatsu, Kawasaki, Kanagawa, 213-8587, Japan. atsuhiko4822gh@gmail.com.
  • Sawa N; Department of Nephrology, Saga University Internal Medicine, Saga, Japan. atsuhiko4822gh@gmail.com.
  • Oba Y; Department of Nephrology and Rheumatology, Toranomon Hospital Kajigaya, 1-3-1, Takatsu, Kawasaki, Kanagawa, 213-8587, Japan.
  • Ikuma D; Okinaka Memorial Institute for Medical Research, Toranomon Hospital, Tokyo, Japan.
  • Sekine A; Department of Nephrology and Rheumatology, Toranomon Hospital Kajigaya, 1-3-1, Takatsu, Kawasaki, Kanagawa, 213-8587, Japan.
  • Yamanouchi M; Department of Nephrology and Rheumatology, Toranomon Hospital Kajigaya, 1-3-1, Takatsu, Kawasaki, Kanagawa, 213-8587, Japan.
  • Hasegawa E; Department of Nephrology and Rheumatology, Toranomon Hospital, Tokyo, Japan.
  • Mizuno H; Department of Nephrology and Rheumatology, Toranomon Hospital Kajigaya, 1-3-1, Takatsu, Kawasaki, Kanagawa, 213-8587, Japan.
  • Suwabe T; Department of Nephrology and Rheumatology, Toranomon Hospital, Tokyo, Japan.
  • Hayashi N; Okinaka Memorial Institute for Medical Research, Toranomon Hospital, Tokyo, Japan.
  • Kono K; Department of Nephrology and Rheumatology, Toranomon Hospital Kajigaya, 1-3-1, Takatsu, Kawasaki, Kanagawa, 213-8587, Japan.
  • Kinowaki K; Department of Nephrology and Rheumatology, Toranomon Hospital Kajigaya, 1-3-1, Takatsu, Kawasaki, Kanagawa, 213-8587, Japan.
  • Ohashi K; Department of Dermatology, Toranomon Hospital, Tokyo, Japan.
  • Miyazono M; Department of Pathology, Toranomon Hospital, Tokyo, Japan.
  • Yamaguchi Y; Department of Pathology, Toranomon Hospital, Tokyo, Japan.
  • Ubara Y; Department of Pathology, Toranomon Hospital, Tokyo, Japan.
CEN Case Rep ; 2023 Dec 06.
Article en En | MEDLINE | ID: mdl-38055184
ABSTRACT
A 62-year-old man with type 2 diabetes was admitted because of a decrease in estimated glomerular filtration rate from 72 to 17.5 mL/min/1.73 m2 in 10 years and development of widespread bullous skin lesions. His hemoglobin A1c level had been maintained at 6.0-7.0% for 10 years with a dipeptidyl peptidase (DPP)-4 inhibitor. Skin biopsy showed typical bullous pemphigoid, and kidney biopsy showed tubulointerstitial nephritis with eosinophilic infiltration and glomerular endothelial cell proliferation. After discontinuing the DPP-4 inhibitor, skin lesions improved, and renal decline slowed. This case indicates that DPP-4 inhibitors can cause not only skin lesions but also renal disease.
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Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: CEN Case Rep Año: 2023 Tipo del documento: Article País de afiliación: Japón
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: CEN Case Rep Año: 2023 Tipo del documento: Article País de afiliación: Japón