Toxicologic and pharmacokinetic evaluation of a case of vancomycin intoxication during continuous ambulatory peritoneal dialysis.
Pharm Weekbl Sci
; 8(6): 293-7, 1986 Dec 12.
Article
en En
| MEDLINE
| ID: mdl-3808914
The use of vancomycin is rapidly increasing due to the emergence of strains of staphylococci resistant to betalactam antibiotics. In this communication the pharmacokinetics of an overdose of vancomycin in a patient during continuous ambulatory peritoneal dialysis (CAPD) is reported. Brainstem auditory evoked potentials (BAEPs) are used to assess ototoxicity. It could be shown that by shortening the dwell time, the apparent CAPD flow was increased and the vancomycin clearance was also increased. This may explain in part the differences in the values of vancomycin t1/2 in this patient (21 h) as compared to other studies (60-120 h). The age of the patient (3.5 years) may also have influenced the t1/2. Using brainstem auditory evoked potentials as a parameter to assess ototoxicity, it was shown that this patient suffered no damage from the overdose.
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Base de datos:
MEDLINE
Asunto principal:
Vancomicina
/
Diálisis Peritoneal Ambulatoria Continua
Límite:
Humans
Idioma:
En
Revista:
Pharm Weekbl Sci
Año:
1986
Tipo del documento:
Article