Etiology, pathology, and host-impaired immunity in medical implant-associated infections.
J Infect Public Health
; 17(2): 189-203, 2024 Feb.
Article
en En
| MEDLINE
| ID: mdl-38113816
ABSTRACT
Host impaired immunity and pathogens adhesion factors are the key elements in analyzing medical implant-associated infections (MIAI). The infection chances are further influenced by surface properties of implants. This review addresses the medical implant-associated pathogens and summarizes the etiology, pathology, and host-impaired immunity in MIAI. Several bacterial and fungal pathogens have been isolated from MIAI; together, they form cross-kingdom species biofilms and support each other in different ways. The adhesion factors initiate the pathogen's adherence on the implant's surface; however, implant-induced impaired immunity promotes the pathogen's colonization and biofilm formation. Depending on the implant's surface properties, immune cell functions get slow or get exaggerated and cause immunity-induced secondary complications resulting in resistant depression and immuno-incompetent fibro-inflammatory zone that compromise implant's performance. Such consequences lead to the unavoidable and straightforward conclusion for the downstream transformation of new ideas, such as the development of multifunctional implant coatings.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Adhesión Bacteriana
/
Infecciones Relacionadas con Prótesis
Límite:
Humans
Idioma:
En
Revista:
J Infect Public Health
/
J. infect. public health
/
Journal infection and public health
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
/
SAUDE PUBLICA
Año:
2024
Tipo del documento:
Article