Recombinant Tissue Plasminogen Activator: The New Concept for Dissolving Septae in Loculated Peri-pancreatic Fluid Collection prior to Endoscopic Drainage. A Case Report.
J Gastrointestin Liver Dis
; 32(4): 554-557, 2023 12 22.
Article
en En
| MEDLINE
| ID: mdl-38147601
ABSTRACT
Peri-pancreatic fluid collections are late complications of acute pancreatitis. Loculated peri-pancreatic fluid collections, even rare, remain the "black sheep" in terms of drainage, due to difficulty to puncture all compartments, thus prohibiting proper drainage of all compartments. Recombined tissue plasminogen activator (r-tPA) has been advocated as treatment of the loculated collections, due to its ability to dissolve the fibrinous strands and thus facilitate proper drainage. We report the case of a 58 years-old male presenting with a painful loculated peri-pancreatic fluid collection secondary to acute pancreatitis. We performed Alteplase injection, followed by successful endosonographic drainage with lumen apposing metal stent of the collection after 48 hours. Our observation suggests that r-tPA could be a new strategy for loculated collections management, ensuring better drainage and limiting the indication for surgical treatment.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Pancreatitis
/
Activador de Tejido Plasminógeno
Límite:
Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Gastrointestin Liver Dis
/
J. gastrointest. liver dis.
/
Journal of gastrointestinal and liver diseases
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2023
Tipo del documento:
Article