Deep Anterior Lamellar Keratoplasty Using Dehydrated versus Standard Organ Culture-Stored Donor Corneas: Prospective Randomized Trial.
Ophthalmology
; 131(6): 674-681, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38160881
ABSTRACT
PURPOSE:
To compare the outcomes of deep anterior lamellar keratoplasty (DALK) using dehydrated versus standard organ culture-stored donor corneas for eyes with keratoconus.DESIGN:
Prospective, randomized, single-center trial conducted in Italy.PARTICIPANTS:
Adult patients (age ≥ 18 years) with keratoconus scheduled for elective DALK.METHODS:
Patients undergoing successful type 1 bubble pneumatic dissection using a standard DALK technique were randomized during surgery to receive either dehydrated (n = 30) or standard organ culture-stored (n = 30) donor corneas. MAIN OUTCOMEMEASURES:
The primary study outcome was best spectacle-corrected visual acuity (BSCVA) 12 months after surgery. Secondary outcomes were refractive astigmatism (RA), endothelial cell density (ECD), and complication rates.RESULTS:
Postoperative BSCVA did not significantly differ between groups at both time points mean difference at 6 months was 0.030 logarithm of the minimum angle of resolution (logMAR; 95% confidence interval [CI], -0.53 to 0.10 logMAR; P = 0.471) and at 12 months was -0.013 logMAR (95% CI, -0.10 to 0.08 logMAR; P = 0.764). No significant differences between groups were observed in terms of postoperative RA and ECD at all time points. In the first 3 days after DALK, an epithelial defect was present in 10 patients (33%) in the organ culture cornea group and in 29 patients (97%) in the dehydrated cornea group. Complete re-epithelialization was achieved by day 7 in all patients (100%) in both groups.CONCLUSIONS:
The study provides evidence that the use of dehydrated corneas is noninferior to the use of standard organ culture donor corneas for DALK. Corneal tissue dehydration represents a viable solution that can allow long-term cornea preservation and avoid wastage of unused corneas. FINANCIAL DISCLOSURE(S) The author(s) have no proprietary or commercial interest in any materials discussed in this article.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Técnicas de Cultivo de Órganos
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Preservación de Órganos
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Donantes de Tejidos
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Agudeza Visual
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Trasplante de Córnea
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Queratocono
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Ophthalmology
Año:
2024
Tipo del documento:
Article
País de afiliación:
Italia