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Dendritic cell therapy for neurospoagioma: Immunomodulation mediated by tumor vaccine.
Qian, Da; Liu, Yuxiang; Zheng, Jie; Cai, Jinquan.
Afiliación
  • Qian D; Department of Burn and Plastic Surgery-Hand Surgery, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People's Hospital, Changshu, 215500, Jiangsu Province, China. drqianda@hotmail.com.
  • Liu Y; Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, 150086, Harbin, China.
  • Zheng J; Department of Burn and Plastic Surgery-Hand Surgery, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People's Hospital, Changshu, 215500, Jiangsu Province, China.
  • Cai J; Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, 150086, Harbin, China. caijinquan666777@126.com.
Cell Death Discov ; 10(1): 11, 2024 Jan 06.
Article en En | MEDLINE | ID: mdl-38184649
ABSTRACT
Neurospagioma, arising from different glial cells such as astrocytes, oligodendrocytes, and ependymal cells, stands as the prevalent intracranial tumor within the central nervous system. Among its variants, glioblastoma (GBM) represents the most aggressive form, characterized by a notably high occurrence rate and a discouragingly low survival prognosis. The formidable challenge posed by glioblastoma underscores its critical importance as a life-threatening ailment. Currently, clinical approaches often involve surgical excision along with a combination of radiotherapy and chemotherapy. However, these treatments frequently result in a notable recurrence rate, accompanied by substantial adverse effects that significantly compromise the overall prognosis. Hence, there is a crucial need to investigate novel and dependable treatment strategies. Dendritic cells (DCs), being specialized antigen-presenting cells (APCs), hold a significant position in both innate and adaptive immune responses. Presently, DC vaccines have gained widespread application in the treatment of various tumors, including neurospoagioma. In this review, we summarize the immunomodulatory effects and related mechanisms of DC vaccines in neurospoagioma as well as the progress of clinical trials to propose possible challenges of DC vaccines and new development directions.

Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Cell Death Discov Año: 2024 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Cell Death Discov Año: 2024 Tipo del documento: Article País de afiliación: China