Constructed competitive endogenous RNA network and patterns of immune infiltration revealing the prognostic signature for cervical cancer.
Epigenomics
; 16(1): 23-39, 2024 Jan.
Article
en En
| MEDLINE
| ID: mdl-38221899
ABSTRACT
Aim:
To investigate the relationship between potential abnormal epigenetic modification and immune cell infiltration in patients with cervical carcinoma. Materials &methods:
RNA expression profiles from The Cancer Genome Atlas database were used to explore the relationship between key biomarkers and tumor-infiltrating immune cells and for clinical specimen validation.Results:
Two nomogram models were developed, one with specific ceRNA and the other based on biological markers of related tumor-infiltrating immune cells. Moreover, a key biomarker (RIPOR2), which was significantly relevant to CD8 T cells.Conclusion:
RIPOR2 and CD8 T cells play a crucial role in the development and progression of cervical carcinoma, suggesting their potential as markers for guiding future therapeutic strategies.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Carcinoma
/
Neoplasias del Cuello Uterino
Tipo de estudio:
Prognostic_studies
Límite:
Female
/
Humans
Idioma:
En
Revista:
Epigenomics
Año:
2024
Tipo del documento:
Article
País de afiliación:
China